Breast Cancer

, Volume 24, Issue 2, pp 254–262

N-acetyltransferase 2 polymorphism and breast cancer risk with smoking: a case control study in Japanese women

  • Akio Hara
  • Naruto Taira
  • Taeko Mizoo
  • Keiko Nishiyama
  • Tomohiro Nogami
  • Takayuki Iwamoto
  • Takayuki Motoki
  • Tadahiko Shien
  • Junji Matsuoka
  • Hiroyoshi Doihara
  • Setsuko Ishihara
  • Hiroshi Kawai
  • Kensuke Kawasaki
  • Youichi Ishibe
  • Yutaka Ogasawara
  • Shinichiro Miyoshi
Original Article

DOI: 10.1007/s12282-016-0696-1

Cite this article as:
Hara, A., Taira, N., Mizoo, T. et al. Breast Cancer (2017) 24: 254. doi:10.1007/s12282-016-0696-1

Abstract

Background

Recent studies have suggested that the association between smoking and breast cancer risk might be modified by polymorphisms in the N-acetyltransferase 2 gene (NAT2). Most of these studies were conducted in Western countries, with few reports from East Asia.

Methods

We conducted a case–control study of 511 breast cancer cases and 527 unmatched healthy controls from December 2010 to November 2011 in Japan. Unconditional logistic regression was used to analyze the association of smoking with breast cancer risk stratified by NAT2 phenotype.

Results

In this population, 11 % of the cases and 10 % of the controls were classified as a slow acetylator phenotype. Compared to never smokers, current smokers had an increased breast cancer risk in multivariate analysis [odds ratio (OR) = 2.27, 95 % confidence interval (95 %CI) = 1.38–3.82]. Subgroup analyses of menopausal status indicated the same tendency. Subgroup analyses of NAT2 phenotype, the ORs in both of rapid and slow acetylator phenotype subgroups were comparable, and no interactions were observed between smoking status and NAT2 phenotype (p = 0.97). A dose-dependent effect of smoking on breast cancer risk was seen for the rapid acetylator phenotype, but not for the slow acetylator phenotype.

Conclusion

Given the high frequency of the rapid acetylator phenotype, these results show that smoking is a risk factor for breast cancer among most Japanese women. It may be of little significance to identify the NAT2 phenotype in the Japanese population.

Keywords

Breast cancer Japanese NAT2 Single nucleotide polymorphism Smoking 

Copyright information

© The Japanese Breast Cancer Society 2016

Authors and Affiliations

  • Akio Hara
    • 1
    • 2
  • Naruto Taira
    • 1
    • 2
  • Taeko Mizoo
    • 1
    • 2
  • Keiko Nishiyama
    • 1
    • 2
  • Tomohiro Nogami
    • 1
    • 2
  • Takayuki Iwamoto
    • 2
  • Takayuki Motoki
    • 2
  • Tadahiko Shien
    • 1
    • 2
  • Junji Matsuoka
    • 2
  • Hiroyoshi Doihara
    • 1
    • 2
  • Setsuko Ishihara
    • 3
  • Hiroshi Kawai
    • 4
  • Kensuke Kawasaki
    • 5
  • Youichi Ishibe
    • 6
  • Yutaka Ogasawara
    • 5
  • Shinichiro Miyoshi
    • 1
  1. 1.Department of General Thoracic Surgery and Breast and Endocrinological SurgeryOkayama University Graduate School of Medicine, Dentistry, and Pharmaceutical SciencesOkayama-cityJapan
  2. 2.Department of Breast and Endocrinological SurgeryOkayama University HospitalOkayamaJapan
  3. 3.Department of RadiologyOkayama Saiseikai General HospitalOkayamaJapan
  4. 4.Department of Breast SurgeryOkayama Rousai HospitalOkayamaJapan
  5. 5.Department of Breast and Endocrinological SurgeryKagawa Prefectural Central HospitalTakamatsuJapan
  6. 6.Department of Breast SurgeryMizushima Kyodo HospitalOkayamaJapan

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