Breast Cancer

, Volume 17, Issue 4, pp 306–309

Breast cancer associated with type 1 neurofibromatosis


    • Breast Surgery UnitArmy General Hospital
  • Georgios Nakos
    • Department of PathologyArmy General Hospital
  • Dimitrios Sambaziotis
    • Department of PathologyArmy General Hospital
  • Stavros Gourgiotis
    • Breast Surgery UnitArmy General Hospital
Case Report

DOI: 10.1007/s12282-009-0119-7

Cite this article as:
Salemis, N.S., Nakos, G., Sambaziotis, D. et al. Breast Cancer (2010) 17: 306. doi:10.1007/s12282-009-0119-7


The association between breast cancer and type 1 neurofibromatosis (NF1) is a rare clinical entity. We herein present the case of a 59-year-old woman, with typical clinical manifestations of NF1, who presented with a painless lump in her right breast, which she had first noticed 8 months earlier. Clinical examination and diagnostic workup were suggestive of a breast carcinoma, and a modified radical mastectomy was performed. Histopathological examination revealed a poorly differentiated invasive ductal breast carcinoma and multiple neurofibromas. The pathological staging was pT2N1a according to TNM/UICC. Delayed presentation of the patient was the result of her mistakenly identifying the breast tumor as a manifestation of NF1 neurofibromatosis.


Breast cancerNeurofibromatosis NF1Von Recklinghausen’s disease

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© The Japanese Breast Cancer Society 2009