Case Report

Breast Cancer

, Volume 17, Issue 4, pp 306-309

First online:

Breast cancer associated with type 1 neurofibromatosis

  • Nikolaos S. SalemisAffiliated withBreast Surgery Unit, Army General Hospital Email author 
  • , Georgios NakosAffiliated withDepartment of Pathology, Army General Hospital
  • , Dimitrios SambaziotisAffiliated withDepartment of Pathology, Army General Hospital
  • , Stavros GourgiotisAffiliated withBreast Surgery Unit, Army General Hospital

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The association between breast cancer and type 1 neurofibromatosis (NF1) is a rare clinical entity. We herein present the case of a 59-year-old woman, with typical clinical manifestations of NF1, who presented with a painless lump in her right breast, which she had first noticed 8 months earlier. Clinical examination and diagnostic workup were suggestive of a breast carcinoma, and a modified radical mastectomy was performed. Histopathological examination revealed a poorly differentiated invasive ductal breast carcinoma and multiple neurofibromas. The pathological staging was pT2N1a according to TNM/UICC. Delayed presentation of the patient was the result of her mistakenly identifying the breast tumor as a manifestation of NF1 neurofibromatosis.


Breast cancer Neurofibromatosis NF1 Von Recklinghausen’s disease