Breast Cancer

, Volume 17, Issue 4, pp 303–305

C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor


    • Department of PathologyUniversity of New Mexico, MSC08 4640
  • Sarah A. Oman
    • Department of PathologyUniversity of New Mexico, MSC08 4640
  • Gulshan Parasher
    • Division of Gastroenterology and Hepatology, Department of Internal MedicineUniversity of New Mexico, MSC08 4640
  • Lisa A. Cerilli
    • Department of PathologyUniversity of New Mexico, MSC08 4640
Case Report

DOI: 10.1007/s12282-009-0116-x

Cite this article as:
Vennapusa, B., Oman, S.A., Parasher, G. et al. Breast Cancer (2010) 17: 303. doi:10.1007/s12282-009-0116-x


A 61-year-old woman with no significant past history underwent gastric biopsies demonstrating a strongly c-kit-positive epithelioid malignancy, initially thought to represent gastrointestinal stromal tumor (GIST). Subsequent clinical and immunohistochemical evaluation proved the neoplasm to represent metastatic lobular carcinoma. This case illustrates that although c-kit is highly specific and sensitive for GIST, its expression may occur in a variety of other neoplasms, some of which morphologically resemble GIST and may present in the gastrointestinal tract as metastases. Therefore, a review of other c-kit-positive lesions is also highlighted.


Breast cancerGastric metastasisC-kitInfiltrating lobular carcinomaGastrointestinal stromal tumor (GIST)


C-kit (c-kit protein, c-kit receptor)

C-kit proto-oncogene/CD117


Gastrointestinal stromal tumors


Gross cystic disease fluid protein



Copyright information

© The Japanese Breast Cancer Society 2009