Case Report

Breast Cancer

, Volume 16, Issue 1, pp 68-71

Primary small cell carcinoma of the breast

  • Takashi HojoAffiliated withBreast Surgery Division, National Cancer Center Hospital Email author 
  • , Takayuki KinoshitaAffiliated withBreast Surgery Division, National Cancer Center Hospital
  • , Tadahiko ShienAffiliated withBreast Surgery Division, National Cancer Center Hospital
  • , Kotoe TeradaAffiliated withBreast Surgery Division, National Cancer Center Hospital
  • , Shigemichi HiroseAffiliated withPathology Division, National Hospital Organization Tokyo Medical Center
  • , You IsobeAffiliated withSurgery Division, National Hospital Organization Tokyo Medical Center
  • , Shunji IkeuchiAffiliated withSurgery Division, National Hospital Organization Tokyo Medical Center
  • , Kiyoshi KubochiAffiliated withSurgery Division, National Hospital Organization Tokyo Medical Center
  • , Sumio MatsumotoAffiliated withSurgery Division, National Hospital Organization Tokyo Medical Center
    • , Akashi-Tanaka SadakoAffiliated withBreast Surgery Division, National Cancer Center Hospital

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Abstract

Primary small cell carcinoma of the breast is a very rare disease, and only a few case reports have described small cell carcinoma of the breast that responds to chemotherapy. Here, we report a case of primary small cell carcinoma of the breast that was treated with surgery and chemotherapy for postoperative local recurrence in the chest wall and metastasis to the liver. The metastatic lesions showed a partial response (PR) to carboplatin and irinotecan, but did not respond to subsequent Taxotere and doxifluridine (5′-DFUR) treatment. We then treated the metastatic lesions with CBDCA and etoposide (VP-16), and were able to stop disease progression. Small cell carcinoma of the breast is as aggressive as its pulmonary counterpart. Therefore, the best therapy for primary small cell carcinoma of the breast may be surgery followed by adjuvant therapy similar to that recommended for small cell lung carcinoma.

Keywords

Breast Small cell carcinoma Chemotherapy