Breast Cancer

, Volume 15, Issue 2, pp 153–158

Basal-like subtype of breast cancer: a review of its unique characteristics and their clinical significance

Authors

    • Breast and Endocrine SurgeryNagoya City University Hospital
Review Article

DOI: 10.1007/s12282-008-0034-3

Cite this article as:
Kobayashi, S. Breast Cancer (2008) 15: 153. doi:10.1007/s12282-008-0034-3

Abstract

Subtyping of breast cancers by means of DNA microarray analyses has given rise to the new concept of the basal-like subtype; this subtype is in effect the equivalent of so-called “triple-negative” breast cancer. Basal-like breast cancer has aggressive characteristics, such as high histological grade, mutation of the TP53 gene, and negative hormone receptors. It tends to occur in relatively young women and is highly correlated with suppression of BRCA1 function. The EGFR gene is often overexpressed in this subtype. Here, research carried out in the last few years into the basal-like subtype of breast cancer will be reviewed.

Keywords

Breast cancer Basal-like subtype Triple negative BRCA1 EGFR

Abbreviations

BRCA1

Breast cancer 1

ER

Estrogen receptor

PgR

Progesterone receptor

HER2

Human epidermal growth factor receptor type2

EGFR

Epidermal growth factor receptor

HG

Histological grade

pCR

Pathological complete response

Copyright information

© The Japanese Breast Cancer Society 2008