Translational Research (R Wheeler, Section Editor)

Current Fungal Infection Reports

, Volume 7, Issue 2, pp 126-131

Understanding Vulvovaginal Candidiasis Through a Community Genomics Approach

  • L. Latey BradfordAffiliated withInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of Medicine
  • , Jacques RavelAffiliated withInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of Medicine Email author 
  • , Vincent BrunoAffiliated withInstitute for Genome Sciences, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of Medicine Email author 

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Abstract

Vulvovaginal candidiasis (VVC), predominantly caused by Candida albicans, is one of the most common types of infectious vaginitis. Extensive study has been directed toward understanding host defenses against this infection, and results remain inconclusive. While many have examined the role of innate and cell-mediated immunity, as well as Candida-specific antibodies and the anti-Candida activity of vaginal epithelial cells, little attention has been given to one of the most important players: the vaginal microbiota. Exploring changes in species composition and gene expression within the vaginal community using high-throughput genomic technologies is invaluable to fully understanding Candida pathogenesis and host response to infection. This integrative perspective of pathogenesis, host response and microbial influence are critical to our ability to improve routine gynecologic care and treatment of vaginal infections.

Keywords

VVC Microbiome Genomics Candida albicans Vagina