Current Fungal Infection Reports

, Volume 6, Issue 4, pp 303–311

Paracoccidioidomycosis: Latin America’s Own Fungal Disorder

Authors

    • Unidad de Micología Médica y Experimental y Laboratorios CIDMICCorporación para Investigaciones Biológicas (CIB)
  • Beatriz L. Gómez
    • Unidad de Micología Médica y Experimental y Laboratorios CIDMICCorporación para Investigaciones Biológicas (CIB)
    • Escuela de Medicina y Ciencias de la SaludUniversidad del Rosario
  • Angela Tobón
    • Unidad de Micología Médica y Experimental y Laboratorios CIDMICCorporación para Investigaciones Biológicas (CIB)
EPIDEMIOLOGICAL ASPECTS OF FUNGAL INFECTIONS (T CHILLER AND J BADDLEY, SECTION EDITORS)

DOI: 10.1007/s12281-012-0114-x

Cite this article as:
Restrepo, A., Gómez, B.L. & Tobón, A. Curr Fungal Infect Rep (2012) 6: 303. doi:10.1007/s12281-012-0114-x

Abstract

Paracoccidioidomycosis (PCM) is a systemic, endemic fungal disorder restricted to Latin America (Mexico to Argentina); Brazil accounts for the largest number of cases. Imported cases diagnosed in North America, Europe and Asia represent patients who had previously lived in recognized endemic areas. Paracoccidioides brasiliensis, the etiologic agent, is a thermally dimorphic fungus that in patients and cultures at 37 ° C adopts a yeast form while at lower temperatures it behaves as a mold that bears the infectious conidia. PCM has a peculiar gender distribution with preference for adult males at a ratio of ≥11 to 1. PCM afflicts predominantly adult males engaged in agriculture. It is mostly a chronic disease with acute/subacute cases accounting for less than 15 % of all reports. Specific diagnosis is established late and although available therapy is usually successful in controlling the fungal infection, patients who survive usually develop residual fibrotic lesions that heavily impair their quality of life.

Keywords

ParacoccidioidomycosisSouth American BlastomycosisParacoccidioides brasiliensisEndemic areasChronicAcute/subacute paracoccidioidomycosisLatencyLaboratory diagnosisManagement

Copyright information

© Springer Science+Business Media New York 2012