Current Fungal Infection Reports

, Volume 6, Issue 1, pp 11–22

Genetic Susceptibility to Fungal Infections in Humans

Current Management of Fungal Infections (L Ostrosky-Zeichner, Section Editor)

DOI: 10.1007/s12281-011-0076-4

Cite this article as:
Lionakis, M.S. Curr Fungal Infect Rep (2012) 6: 11. doi:10.1007/s12281-011-0076-4

Abstract

Most fungal infections in humans occur in the setting of iatrogenic immunosuppression or HIV infection. In the absence of these factors, fungi cause mild, self-limited infections that typically involve mucocutaneous surfaces. Hence, when persistent or recurrent mucocutaneous infections (chronic mucocutaneous candidiasis [CMC]) or invasive fungal infections (IFIs) develop in a “normal” host, they are indicative of genetic defects causing innate or adaptive immune dysfunction. In this review, recent developments concerning genetic and immunologic factors that affect the risk for IFIs and CMC are critically discussed.

Keywords

Fungal infection Genetics Susceptibility Immune dysfunction Primary immunodeficiency Chronic mucocutaneous candidiasis Chronic granulomatous disease Hyper-IgE syndrome MonoMAC Leukocyte adhesion deficiency Severe combined immunodeficiency Hyper-IgM syndrome APECED STAT1 STAT3 CARD9 DOCK8 Dectin-1 Toll-like receptors IL-17 IL-12/IFN-γ axis 

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  1. 1.National Institutes of HealthBethesdaUSA

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