The Journal of Microbiology

, Volume 49, Issue 2, pp 193–199

Inhibitory effect of Lactobacillus reuteri on periodontopathic and cariogenic bacteria

Authors

  • Mi-Sun Kang
    • Department of Microbiology, School of MedicineChonnam National University
  • Jong-Suk Oh
    • Department of Microbiology, School of MedicineChonnam National University
  • Hyun-Chul Lee
    • Department of Microbiology, School of MedicineChonnam National University
  • Hoi-Soon Lim
    • Dental Science Research InstituteChonnam National University
  • Seok-Woo Lee
    • Department of PeriodonticsChonnam National University
    • Division of Periodontics, School of DentistryMarquette University
  • Kyu-Ho Yang
    • Dental Science Research InstituteChonnam National University
    • Department of Pediatric DentistryChonnam National University
  • Nam-Ki Choi
    • Dental Science Research InstituteChonnam National University
    • Department of Pediatric DentistryChonnam National University
    • Dental Science Research InstituteChonnam National University
    • Department of Pediatric DentistryChonnam National University
Articles

DOI: 10.1007/s12275-011-0252-9

Cite this article as:
Kang, M., Oh, J., Lee, H. et al. J Microbiol. (2011) 49: 193. doi:10.1007/s12275-011-0252-9

Abstract

The interaction between Lactobacillus reuteri, a probiotic bacterium, and oral pathogenic bacteria have not been studied adequately. This study examined the effects of L. reuteri on the proliferation of periodontopathic bacteria including Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, and on the formation of Streptococcus mutans biofilms. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of periodontopathic bacteria and the formation of S. mutans biofilms. These antibacterial activities of L. reuteri were attributed to the production of organic acids, hydrogen peroxide, and a bacteriocin-like compound. Reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. In addition, L. reuteri inhibited the production of methyl mercaptan by F. nucleatum and P. gingivalis. Overall, these results suggest that L. reuteri may be useful as a probiotic agent for improving oral health.

Keywords

Lactobacillus reuteriperiodontopathic bacteriaStreptococcus mutansinhibitory effectbiofilms

Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2011