The Journal of Microbiology

, Volume 46, Issue 6, pp 744–750

Inhibitory effect of methyl gallate and gallic acid on oral bacteria

Authors

  • Mi-Sun Kang
    • Department of Microbiology, School of MedicineChonnam National University
  • Jong-Suk Oh
    • Department of Microbiology, School of MedicineChonnam National University
  • In-Chol Kang
    • Brain Korea 21 ProgramChonnam National University
    • Dental Science Research InstituteChonnam National University
  • Suk-Jin Hong
    • Dental Science Research InstituteChonnam National University
    • Department of Preventive and Public Health DentistryChonnam National University
    • Dental Science Research InstituteChonnam National University
    • Department of Preventive and Public Health DentistryChonnam National University
Article

DOI: 10.1007/s12275-008-0235-7

Cite this article as:
Kang, M., Oh, J., Kang, I. et al. J Microbiol. (2008) 46: 744. doi:10.1007/s12275-008-0235-7

Abstract

This study examined the ability of methyl gallate (MG) and gallic acid (GA), the main compounds of gallo-tannins in Galla Rhois, to inhibit the proliferation of oral bacterial and the in vitro formation of Streptococcus mutans biofilms. The antimicrobial activities of these compounds were evaluated in vitro using the broth microdilution method and a beaker-wire test. Both MG and GA had inhibitory effects on the growth of cariogenic (MIC<8 mg/ml) and periodontopathic bacteria (MIC=1 mg/ml). Moreover, these compounds significantly inhibited the in vitro formation of S. mutans biofilms (MG, 1 mg/ml; GA, 4 mg/ml; P<0.05). MG was more effective in inhibiting bacterial growth and the formation of S. mutans biofilm than GA. In conclusion, MG and GA can inhibit the growth of oral pathogens and S. mutans biofilm formation, and may be used to prevent the formation of oral biofilms.

Keywords

antibacterial activityGalla Rhoisgallic acidmethyl gallateoral bacteria

Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelber GmbH 2008