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Facile synthesis of magnetic–plasmonic nanocomposites as T 1 MRI contrast enhancing and photothermal therapeutic agents

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Abstract

Nanocomposites combining magnetic and plasmonic components have received widespread attention in recent years due to their potential applications in biomedical research. Herein, we describe a facile method for growing small iron oxide nanoparticles on various plasmonic core materials with different shapes and surfaces by utilizing a polypyrrole interlayer. By focusing on Au nanorod@polypyrrole@iron oxide (Au NR@PPy@Fe x O) nanocomposites, we show that these systems exhibit a low r 2/r 1 ratio of 4.8, making them efficient T 1 positive contrast-enhancing agents for magnetic resonance imaging (MRI). Moreover, we show that the nanocomposites are excellent photothermal agents in the second near infrared region, with high photothermal conversion efficiency, reaching up to 46%. In addition, the Au NR@PPy@Fe x O nanocomposites show very low cytotoxicity. In summary, the present results highlight the great potential of the synthetic method and the nanocomposites developed in this study for T 1 MRI and/or infrared thermal imaging-guided photothermal cancer therapeutic applications.

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Authors and Affiliations

  1. Key Laboratory of Nano-Bio Interface, i-lab and Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China

    Zhongzhen Yang, Xianguang Ding & Jiang Jiang

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Zhongzhen Yang & Xianguang Ding

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  1. Zhongzhen Yang
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  2. Xianguang Ding
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Yang, Z., Ding, X. & Jiang, J. Facile synthesis of magnetic–plasmonic nanocomposites as T 1 MRI contrast enhancing and photothermal therapeutic agents. Nano Res. 9, 787–799 (2016). https://doi.org/10.1007/s12274-015-0958-9

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