Nano Research

, Volume 6, Issue 9, pp 627–634

Enhanced and tunable fluorescent quantum dots within a single crystal of protein

Authors

  • Hui Wei
    • Department of ChemistryUniversity of Illinois at Urbana-Champaign
  • Stephen House
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
  • Jiangjiexing Wu
    • Department of ChemistryUniversity of Illinois at Urbana-Champaign
    • Key Laboratory for Green Chemical Technology MOETianjin University
  • Jiong Zhang
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
  • Zidong Wang
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
  • Ying He
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
  • Elizabeth J. Gao
    • Department of ChemistryUniversity of Illinois at Urbana-Champaign
  • Yigui Gao
    • George L. Clark X-Ray Facility and 3M Materials LaboratoryUniversity of Illinois at Urbana-Champaign
  • Howard Robinson
    • Department of BiologyBrookhaven National Laboratory
  • Wei Li
    • Key Laboratory for Green Chemical Technology MOETianjin University
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
    • Department of ChemistryUniversity of Illinois at Urbana-Champaign
    • Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign
Research Article

DOI: 10.1007/s12274-013-0348-0

Cite this article as:
Wei, H., House, S., Wu, J. et al. Nano Res. (2013) 6: 627. doi:10.1007/s12274-013-0348-0

Abstract

The design and synthesis of bio-nano hybrid materials can not only provide new materials with novel properties, but also advance our fundamental understanding of interactions between biomolecules and their abiotic counterparts. Here, we report a new approach to achieving such a goal by growing CdS quantum dots (QDs) within single crystals of lysozyme protein. This bio-nano hybrid emitted much stronger red fluorescence than its counterpart without the crystal, and such fluorescence properties could be either enhanced or suppressed by the addition of Ag(I) or Hg(II), respectively. The three-dimensional incorporation of CdS QDs within the lysozyme crystals was revealed by scanning transmission electron microscopy with electron tomography. More importantly, since our approach did not disrupt the crystalline nature of the lysozyme crystals, the metal and protein interactions were able to be studied by X-ray crystallography, thus providing insight into the role of Cd(II) in the CdS QDs formation.
https://static-content.springer.com/image/art%3A10.1007%2Fs12274-013-0348-0/MediaObjects/12274_2013_348_Fig1_HTML.gif

Keywords

functional bio-nanomaterialsquantum dotsprotein single crystalsX-ray crystallographytomography

Supplementary material

12274_2013_348_MOESM1_ESM.pdf (776 kb)
Supplementary material, approximately 772 KB.

Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2013