Archives of Pharmacal Research

, Volume 37, Issue 1, pp 16-23

First online:

Extracellular stability of nanoparticulate drug carriers

  • Karen C. LiuAffiliated withWeldon School of Biomedical Engineering, Purdue University
  • , Yoon YeoAffiliated withWeldon School of Biomedical Engineering, Purdue UniversityDepartment of Industrial and Physical Pharmacy, Purdue UniversityBiomedical Research Institute, Korea Institute of Science and Technology Email author 

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Nanoparticulate (NP) drug carrier systems are attractive vehicles for selective drug delivery to solid tumors. Ideally, NPs should evade clearance by the reticuloendothelial system while maintaining the ability to interact with tumor cells and facilitate cellular uptake. Great effort has been made to fulfill these design criteria, yielding various types of functionalized NPs. Another important consideration in NP design is the physical and functional stability during circulation, which, if ignored, can significantly undermine the promise of intelligently designed NP drug carriers. This commentary reviews several NP examples with stability issues and their consequences, ending in a discussion of experimental methods for reliable prediction of NP stability.


Nanomedicine Nanoparticles Drug delivery Stability Sensitivity