Archives of Pharmacal Research

, Volume 37, Issue 4, pp 467–472

A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects

  • Hyun Gyu Choi
  • Yeon Ho Choi
  • Ji Hyang Kim
  • Hui-Hun Kim
  • Sang-Hyun Kim
  • Jeong Ah Kim
  • Sang Myung Lee
  • MinKyun Na
  • Seung Ho Lee
Research Article

DOI: 10.1007/s12272-013-0239-7

Cite this article as:
Choi, H.G., Choi, Y.H., Kim, J.H. et al. Arch. Pharm. Res. (2014) 37: 467. doi:10.1007/s12272-013-0239-7

Abstract

A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher’s esterification. The effect of compounds 17 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.

Keywords:

Lindera obtusilobaLignanLinderin AAnti-allergic effect

Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Hyun Gyu Choi
    • 1
  • Yeon Ho Choi
    • 1
  • Ji Hyang Kim
    • 1
  • Hui-Hun Kim
    • 2
  • Sang-Hyun Kim
    • 2
  • Jeong Ah Kim
    • 3
  • Sang Myung Lee
    • 4
  • MinKyun Na
    • 5
  • Seung Ho Lee
    • 1
  1. 1.College of PharmacyYeungnam UniversityGyeongsanKorea
  2. 2.Laboratory of Immunotoxicology, Department of Pharmacology, School of MedicineKyungpook National UniversityDaeguKorea
  3. 3.Research Institute of Pharmaceutical Science, College of PharmacyKyungpook National UniversityDaeguKorea
  4. 4.Korea Ginseng Corp., Central Research InstituteDaejeonKorea
  5. 5.College of PharmacyChungnam National UniversityDaejeonKorea