Research Article

Archives of Pharmacal Research

, Volume 37, Issue 4, pp 467-472

First online:

A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects

  • Hyun Gyu ChoiAffiliated withCollege of Pharmacy, Yeungnam University
  • , Yeon Ho ChoiAffiliated withCollege of Pharmacy, Yeungnam University
  • , Ji Hyang KimAffiliated withCollege of Pharmacy, Yeungnam University
  • , Hui-Hun KimAffiliated withLaboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, Kyungpook National University
  • , Sang-Hyun KimAffiliated withLaboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, Kyungpook National University
  • , Jeong Ah KimAffiliated withResearch Institute of Pharmaceutical Science, College of Pharmacy, Kyungpook National University
  • , Sang Myung LeeAffiliated withKorea Ginseng Corp., Central Research Institute
  • , MinKyun NaAffiliated withCollege of Pharmacy, Chungnam National University Email author 
  • , Seung Ho LeeAffiliated withCollege of Pharmacy, Yeungnam University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher’s esterification. The effect of compounds 17 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.

Keywords:

Lindera obtusiloba Lignan Linderin A Anti-allergic effect