Archives of Pharmacal Research

, Volume 37, Issue 4, pp 467–472

A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects

Authors

  • Hyun Gyu Choi
    • College of PharmacyYeungnam University
  • Yeon Ho Choi
    • College of PharmacyYeungnam University
  • Ji Hyang Kim
    • College of PharmacyYeungnam University
  • Hui-Hun Kim
    • Laboratory of Immunotoxicology, Department of Pharmacology, School of MedicineKyungpook National University
  • Sang-Hyun Kim
    • Laboratory of Immunotoxicology, Department of Pharmacology, School of MedicineKyungpook National University
  • Jeong Ah Kim
    • Research Institute of Pharmaceutical Science, College of PharmacyKyungpook National University
  • Sang Myung Lee
    • Korea Ginseng Corp., Central Research Institute
    • College of PharmacyChungnam National University
    • College of PharmacyYeungnam University
Research Article

DOI: 10.1007/s12272-013-0239-7

Cite this article as:
Choi, H.G., Choi, Y.H., Kim, J.H. et al. Arch. Pharm. Res. (2014) 37: 467. doi:10.1007/s12272-013-0239-7

Abstract

A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher’s esterification. The effect of compounds 17 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells. Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects.

Keywords:

Lindera obtusilobaLignanLinderin AAnti-allergic effect

Copyright information

© The Pharmaceutical Society of Korea 2013