Archives of Pharmacal Research

, Volume 37, Issue 5, pp 580–587

Synthesis and cytotoxic evaluation of novel N-substituted amidino-1-hydroxybenzimidazole derivatives

  • Mehmet Alp
  • Hakan Göker
  • Tulin Ozkan
  • Asuman Sunguroglu
Research Article

DOI: 10.1007/s12272-013-0197-0

Cite this article as:
Alp, M., Göker, H., Ozkan, T. et al. Arch. Pharm. Res. (2014) 37: 580. doi:10.1007/s12272-013-0197-0
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Abstract

A new class of N-substituted amidino-1-hydroxybenzimidazole derivatives (15–24) were synthesized and evaluated for their in vitro cytotoxic activities against human leukemia cell lines, HL-60 and K562. The preliminary results showed that compounds 16, 20, 21 and 23 had moderate antitumor activity against HL-60 cell line. Further investigation on the mechanism of the observed cytotoxic effects demonstrated that compound 21 increased the expression of autophagic and apoptotic genes and induced apoptosis of HL-60 cells.

Keywords

1H-benzimidazoleAmidinobenzimidazoleCytotoxic activityK562HL-60

Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Mehmet Alp
    • 1
  • Hakan Göker
    • 1
  • Tulin Ozkan
    • 2
  • Asuman Sunguroglu
    • 2
  1. 1.Department of Pharmaceutical Chemistry, Faculty of PharmacyAnkara UniversityTandoganTurkey
  2. 2.Department of Medical Biology, Faculty of MedicineAnkara UniversitySıhhiyeTurkey