Archives of Pharmacal Research

, Volume 36, Issue 7, pp 792–801

The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents


    • Department of DermatologyDongguk University Seoul, Graduate School of Medicine
  • Minsoo Noh
    • Department of PharmacyAjou University

DOI: 10.1007/s12272-013-0130-6

Cite this article as:
Lee, A. & Noh, M. Arch. Pharm. Res. (2013) 36: 792. doi:10.1007/s12272-013-0130-6


Abnormal pigmentation, particularly hyperpigmentation, is major issue of concern for people with colored skin. Several hypopigmenting agents, which exert their action by inhibiting tyrosinase activity and/or transcription, have been used for treatment. However, results have been discouraging. To manage abnormal pigmentation properly, the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis via intracellular machineries. cAMP and PKC are critical factors of important transduction pathways and cross-talk between them could amplify the melanogenic effect. Here, factors involved in melanogenesis regulation via cAMP and/or PKC pathways are reviewed with their action mechanisms.


MelanogenesiscAMPPKCHypopigmenting agents

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© The Pharmaceutical Society of Korea 2013