Archives of Pharmacal Research

, Volume 36, Issue 2, pp 230–236

Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy

  • Shinji Kume
  • Munehiro Kitada
  • Keizo Kanasaki
  • Hiroshi Maegawa
  • Daisuke Koya
Review

DOI: 10.1007/s12272-013-0019-4

Cite this article as:
Kume, S., Kitada, M., Kanasaki, K. et al. Arch. Pharm. Res. (2013) 36: 230. doi:10.1007/s12272-013-0019-4

Abstract

Caloric restriction prolongs the lifespan of many species. Therefore, investigators have researched the usefulness of caloric restriction for healthy lifespan extension. Sirt1, an NAD+-dependent deacetylase, was identified as a molecule necessary for caloric restriction-related anti-aging strategies. Sirt1 functions as an intracellular energy sensor to detect the concentration of NAD+, and controls in vivo metabolic changes under caloric restriction and starvation through its deacetylase activity to many targets including histones, nuclear transcriptional factors, and enzymes. During the past decade, investigators have reported the relationship between disturbance of Sirt1 activation and the onset of aging- and obesity-associated diseases such as diabetes, cardiovascular disease and neurodegenerative disorders. Consequently, a calorie restriction-mimetic action of Sirt1 is now expected as a new therapy for these diseases. In addition, recent studies have gradually clarified the role of Sirt1 in the onset of kidney disease. Its activation may also become a new target of treatment in the patients with chronic kidney disease including diabetic nephropathy. In this article, we would like to review the role of Sirt1 in the onset of kidney disease based on previous studies, and discuss its possibility as the target of treatment in diabetic nephropathy.

Keywords

Diabetic nephropathy Sirt1 Sirtuin Calorie restriction Autophagy 

Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Shinji Kume
    • 1
  • Munehiro Kitada
    • 2
  • Keizo Kanasaki
    • 2
  • Hiroshi Maegawa
    • 1
  • Daisuke Koya
    • 2
  1. 1.Department of MedicineShiga University of Medical ScienceOtsuJapan
  2. 2.Division of Diabetes & EndocrinologyKanazawa Medical UniversityIshikawaJapan