Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors
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- Liu, Y., Lu, WQ., Cui, KQ. et al. Arch. Pharm. Res. (2012) 35: 1525. doi:10.1007/s12272-012-0902-4
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A series of novel artemisinin derivatives were synthesized from artemisinin and different anilines. All compounds were obtained as β-isomers. The target compounds were evaluated for inhibition activity against Plasmodium falciparum falcipain-2 in vitro, and most of them exhibited potent inhibition in the low micromolar range and proved to be new types of falcipain-2 inhibitors.