Archives of Pharmacal Research

, Volume 35, Issue 4, pp 633–638

Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: A novel class of neuraminidase inhibitors

  • Mayank Kinger
  • Yong Dae Park
  • Jeong Hoon Park
  • Min Goo Hur
  • Hyung Jae Jeong
  • Su-Jin Park
  • Woo Song Lee
  • Sang Wook Kim
  • Seung Dae Yang
Research Articles Drug Design and Discovery

DOI: 10.1007/s12272-012-0406-2

Cite this article as:
Kinger, M., Park, Y.D., Park, J.H. et al. Arch. Pharm. Res. (2012) 35: 633. doi:10.1007/s12272-012-0406-2

Abstract

A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 ∝M.

Key words

Anti-influenza activity Synthesis Neuraminidase 1,3-Diarylprop-2-en-1-ones 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2012

Authors and Affiliations

  • Mayank Kinger
    • 1
  • Yong Dae Park
    • 1
  • Jeong Hoon Park
    • 1
  • Min Goo Hur
    • 1
  • Hyung Jae Jeong
    • 2
  • Su-Jin Park
    • 2
  • Woo Song Lee
    • 2
  • Sang Wook Kim
    • 3
  • Seung Dae Yang
    • 1
  1. 1.Advanced Radiation Technology InstituteKorea Atomic Energy Research InstituteJeongupKorea
  2. 2.Infection Control Research Center and AI Control Research CenterKRIBBJeongupKorea
  3. 3.Department of Nanomaterial Chemistry, College of Science & TechnologyDongguk UniversityGyeongjuKorea

Personalised recommendations