Report on Investigational Drugs

Archives of Pharmacal Research

, Volume 35, Issue 2, pp 197-200

First online:

Multi-targeted hybrids based on HDAC inhibitors for anti-cancer drug discovery

  • Seung-Yong SeoAffiliated withCollege of Pharmacy, Woosuk University Email author 

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Multi-targeted hybrids combine two drugs in a single molecule to have greater medicinal effects than its individual components. Recently, a number of anti-cancer drug candidates such as CUDC-101 (Curis) have been designed based on linking properly two selected pharmacophores endowed with activity against different therapeutic targets.