Archives of Pharmacal Research

, Volume 35, Issue 2, pp 201-211

First online:

Perspectives on mesenchymal stem cells: Tissue repair, immune modulation, and tumor homing

  • Hyun Sook HongAffiliated withDepartment of Genetic Engineering & Graduate School of Biotechnology, Kyung Hee University
  • , Yeong Hoon KimAffiliated withDepartment of Ophthalmology, College of Medicine, The Catholic University of Korea, St. Paul’s Hospital
  • , Youngsook SonAffiliated withDepartment of Genetic Engineering & Graduate School of Biotechnology, Kyung Hee UniversityDepartment of Genetic Engineering, College of Life Science, Kyung Hee University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Mesenchymal stem cells (MSCs) or MSC-like cells have been identified in a variety of different tissues that share molecular expression profiles and biological functions but also retain a unique differentiation preference depending on their tissue origins. MSCs play beneficial roles in the healing of damaged tissue by directly differentiating to many different resident cell types and/or by secreting several trophic factors that aid tissue repair. Aside from MSCs’ reparative stem cell function, they drive immune responses toward immunosuppression and anti-inflammation. This novel function of MSCs opens up new avenues for clinical development of MSC immune-therapeutics to treat uncontrollable, life threatening, severe, chronic inflammation and autoimmune disease. Unexpectedly high rates of MSCs’ tumor homing capacity and their tumor supporting capability have also been noted in tumor-bearing animal models. In this review, we will discuss MSCs’ basic cell biology and perspectives on MSCs in terms of tissue repair, immune modulation, and tumor homing.

Key words

MSC Tissue repair Immune modulation Tumor homing Adipose stem cell Inflammation