Archives of Pharmacal Research

, Volume 34, Issue 11, pp 1887–1897

Designing micro- and nano-particles for treating rheumatoid arthritis

Review

DOI: 10.1007/s12272-011-1109-9

Cite this article as:
Mitragotri, S. & Yoo, JW. Arch. Pharm. Res. (2011) 34: 1887. doi:10.1007/s12272-011-1109-9

Abstract

Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disease that can cause disability and have a negative socioeconomic impact. Despite significant advances in therapeutic options, limitations on the routes of administration and the requirement for frequent and long-term dosing often lead to systemic adverse effects and patient non-compliance. Micro and nanoparticle systems that selectively deliver drugs to inflamed synovium have the potential to improve drug efficacy while leaving extrasynovial tissues unaffected. This review summarizes key design parameters of RA-targeted drug carriers and discusses design considerations for improving RA therapies.

Key words

Rheumatoid arthritisDrug carriersMicroparticlesNanoparticlesTargeted drug deliverySizeSurface chemistryShape

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  1. 1.Department of Chemical EngineeringUniversity of CaliforniaSanta BarbaraUSA
  2. 2.BK21 Project Team, College of PharmacyChosun UniversityGwangjuKorea
  3. 3.College of PharmacyChosun UniversityGwangjuKorea