Archives of Pharmacal Research

, 34:1263

Anti-inflammatory cembranoids from the Formosan soft coral Sinularia discrepans

  • Yi Lu
  • Huey-Jen Su
  • Yung-Husan Chen
  • Zhi-Hong Wen
  • Jyh-Horng Sheu
  • Jui-Hsin Su
Research Articles Drug Design and Discovery

DOI: 10.1007/s12272-011-0804-x

Cite this article as:
Lu, Y., Su, HJ., Chen, YH. et al. Arch. Pharm. Res. (2011) 34: 1263. doi:10.1007/s12272-011-0804-x

Abstract

A new cembranoid, discrepanolide A (1), along with four known cembranoids 2–5 were isolated from the Formosan soft coral Sinularia discrepans. The structures of these compounds were determined by analysis of spectroscopic data and by comparison of NMR data with those of known compounds. None of these compounds were found to be cytotoxic towards a limited panel of cancer cell lines. Compounds 3–5 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 5 also significantly inhibited the accumulation of pro-inflammatory COX-2 protein.

Key words

Soft coral Sinularia discrepans Discrepanolide Anti-inflammatory activity 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Yi Lu
    • 1
  • Huey-Jen Su
    • 2
  • Yung-Husan Chen
    • 3
  • Zhi-Hong Wen
    • 1
    • 4
  • Jyh-Horng Sheu
    • 1
    • 4
  • Jui-Hsin Su
    • 3
    • 5
  1. 1.Department of Marine Biotechnology and ResourcesNational Sun Yat-sen UniversityKaohsiungTaiwan
  2. 2.Department of NursingMeiho UniversityNeipu Hsiang, PingtungTaiwan
  3. 3.National Museum of Marine Biology & AquariumChecheng, PingtungTaiwan
  4. 4.Asia-Pacific Ocean Research CenterNational Sun Yat-sen UniversityKaohsiungTaiwan
  5. 5.Graduate Institute of Marine BiotechnologyNational Dong Hwa UniversityChecheng, PingtungTaiwan

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