Archives of Pharmacal Research

, Volume 34, Issue 6, pp 971–978

Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum

  • Myung-Hoe Kim
  • Agung Nugroho
  • Jongwon Choi
  • Jong Hee Park
  • Hee-Juhn Park
Research Articles Drug Development

DOI: 10.1007/s12272-011-0614-1

Cite this article as:
Kim, MH., Nugroho, A., Choi, J. et al. Arch. Pharm. Res. (2011) 34: 971. doi:10.1007/s12272-011-0614-1

Abstract

To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (−)-rhododendrol, (−)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity.

Key words

Rhododendron aureum Ericaceae Rhododendrin Antinociceptive Anti-inflammatory 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Myung-Hoe Kim
    • 1
  • Agung Nugroho
    • 2
  • Jongwon Choi
    • 3
  • Jong Hee Park
    • 4
  • Hee-Juhn Park
    • 1
  1. 1.Department of Pharmaceutical EngineeringSangji UniversityWonjuKorea
  2. 2.Department of Agro-industrial Technology, Faculty of AgricultureLambung Mangkurat UniversityBanjarbaruIndonesia
  3. 3.College of PharmacyKyungsung UniversityBusanKorea
  4. 4.College of PharmacyPusan National UniversityBusanKorea

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