Archives of Pharmacal Research

, Volume 34, Issue 6, pp 907–912

Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium

  • Xiao-Ping Peng
  • Yi Wang
  • Pei-Pei Liu
  • Kui Hong
  • Hao Chen
  • Xia Yin
  • Wei-Ming Zhu
Research Articles Drug Design and Discovery

DOI: 10.1007/s12272-011-0607-0

Cite this article as:
Peng, XP., Wang, Y., Liu, PP. et al. Arch. Pharm. Res. (2011) 34: 907. doi:10.1007/s12272-011-0607-0

Abstract

A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher’s method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 μM. The absolute configurations of compounds 2–4 were determined for the first time.

Key words

Halotolerant fungusWallemia sebiAntibacterial activityCyclopentanopyridine alkaloid

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Xiao-Ping Peng
    • 1
  • Yi Wang
    • 1
  • Pei-Pei Liu
    • 1
  • Kui Hong
    • 2
  • Hao Chen
    • 3
  • Xia Yin
    • 1
  • Wei-Ming Zhu
    • 1
    • 4
  1. 1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of ChinaQingdaoChina
  2. 2.Institute of Tropical Biological Sciences and BiotechnologyChinese Academy of Tropical Agricultural ScienceHaikouChina
  3. 3.First Institute of OceanographyState Oceanic AdministrationQingdaoChina
  4. 4.School of Medicine and PharmacyOcean University of ChinaQingdaoChina