Archives of Pharmacal Research

, Volume 34, Issue 6, pp 907–912

Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium

Authors

  • Xiao-Ping Peng
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of China
  • Yi Wang
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of China
  • Pei-Pei Liu
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of China
  • Kui Hong
    • Institute of Tropical Biological Sciences and BiotechnologyChinese Academy of Tropical Agricultural Science
  • Hao Chen
    • First Institute of OceanographyState Oceanic Administration
  • Xia Yin
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of China
    • Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and PharmacyOcean University of China
    • School of Medicine and PharmacyOcean University of China
Research Articles Drug Design and Discovery

DOI: 10.1007/s12272-011-0607-0

Cite this article as:
Peng, X., Wang, Y., Liu, P. et al. Arch. Pharm. Res. (2011) 34: 907. doi:10.1007/s12272-011-0607-0

Abstract

A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher’s method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 μM. The absolute configurations of compounds 2–4 were determined for the first time.

Key words

Halotolerant fungusWallemia sebiAntibacterial activityCyclopentanopyridine alkaloid

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011