Research Articles Drug Design and Discovery

Archives of Pharmacal Research

, Volume 34, Issue 6, pp 881-886

A new phenolic compound with anticancer activity from the wood of Millettia leucantha

  • Kanok-on RayanilAffiliated withDepartment of Chemistry, Faculty of Science, Silpakorn University Email author 
  • , Pastraporn BunchornmaspanAffiliated withDepartment of Chemistry, Faculty of Science, Silpakorn University
  • , Pittaya TuntiwachwuttikulAffiliated withDepartment of Chemistry, Faculty of Science, Silpakorn University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol (1), along with six known compounds, medicarpin (2), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (3), 5,4′-dihydroxy-7,8-dimethoxyisoflavone (4), physcion (5), (R)-(-)-mellein (6) and isoliquiritigenin (7), were isolated from the wood of Millettia leucantha. The structures of the compounds were determined by an analysis of their spectroscopic data. Some of the isolates were tested for anticancer activity. Compound 1 exhibited strong cytotoxicity against the BCA-1 tumor cell lines with an IC50 = 3.44 μg/mL.

Key words

Millettia leucantha Leguminosae Phenolic compounds Anticancer activity Millettinol