Archives of Pharmacal Research

, Volume 34, Issue 6, pp 881–886

A new phenolic compound with anticancer activity from the wood of Millettia leucantha

  • Kanok-on Rayanil
  • Pastraporn Bunchornmaspan
  • Pittaya Tuntiwachwuttikul
Research Articles Drug Design and Discovery

DOI: 10.1007/s12272-011-0603-4

Cite this article as:
Rayanil, K., Bunchornmaspan, P. & Tuntiwachwuttikul, P. Arch. Pharm. Res. (2011) 34: 881. doi:10.1007/s12272-011-0603-4
  • 300 Downloads

Abstract

A new phenolic compound, 1-(3-hydroxy-4-methoxyphenyl)-3-(2,4-dihydroxy-5-methoxyphenyl) propan-1-ol, named as millettinol (1), along with six known compounds, medicarpin (2), 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (3), 5,4′-dihydroxy-7,8-dimethoxyisoflavone (4), physcion (5), (R)-(-)-mellein (6) and isoliquiritigenin (7), were isolated from the wood of Millettia leucantha. The structures of the compounds were determined by an analysis of their spectroscopic data. Some of the isolates were tested for anticancer activity. Compound 1 exhibited strong cytotoxicity against the BCA-1 tumor cell lines with an IC50 = 3.44 μg/mL.

Key words

Millettia leucanthaLeguminosaePhenolic compoundsAnticancer activityMillettinol

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Kanok-on Rayanil
    • 1
  • Pastraporn Bunchornmaspan
    • 1
  • Pittaya Tuntiwachwuttikul
    • 1
  1. 1.Department of Chemistry, Faculty of ScienceSilpakorn UniversityNakorn PathomThailand