Archives of Pharmacal Research

, Volume 34, Issue 1, pp 147–152

Antibacterial activities of macrolactin a and 7-O-succinyl macrolactin a from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus

  • Dong Hee Kim
  • Hye Kyung Kim
  • Kang Min Kim
  • Chun Kyu Kim
  • Min Ho Jeong
  • Chan Young Ko
  • Kyung Ho Moon
  • Jae Seon Kang
Drug Actions

DOI: 10.1007/s12272-011-0117-0

Cite this article as:
Kim, D.H., Kim, H.K., Kim, K.M. et al. Arch. Pharm. Res. (2011) 34: 147. doi:10.1007/s12272-011-0117-0

Abstract

The principal objective of this study was to evaluate the antibacterial activities of macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA) generated from Bacillus polyfermenticus KJS-2 against vancomycin-resistant enterococci (VREs) and methicillin-resistant Staphylococcus aureus. The minimal inhibitory concentrations (MICs) of MA and SMA against VREs were 16 and 2∼1 μg/mL, respectively, and the MICs of MA and SMA against methicillin-resistant Staphylococcus aureus were 2 and < 0.25 μg/mL, respectively. Their MIC values were comparable or superior to those of teicoplanin. In evaluating the inhibitory effects of intestinal VRE colonization in mice, the oral MA and SMA effected a rapid inhibition of intestinal VRE colonization in mice, and the intraperitoneal SMA also inhibited VRE colonization, whereas intraperitoneal MA did not.

Key words

Macrolactin A 7-O-succinyl macrolactin A Vancomycin-resistant enterococci, Methicillin-resistant Staphylococcus aureus Antibacterial activity 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Dong Hee Kim
    • 1
  • Hye Kyung Kim
    • 2
  • Kang Min Kim
    • 3
  • Chun Kyu Kim
    • 3
  • Min Ho Jeong
    • 4
  • Chan Young Ko
    • 5
  • Kyung Ho Moon
    • 6
  • Jae Seon Kang
    • 6
  1. 1.Research and Development CenterDaewoo Pharm. Co. Ltd.GimhaeKorea
  2. 2.Clinical Trial Center For Functional FoodsChonbuk National University HospitalJeonjuKorea
  3. 3.Department of Smart Foods and DrugsInje UniversityGimhaeKorea
  4. 4.Dong-A University Medical Science Research CenterBusanKorea
  5. 5.College of PharmacySungkyunkwan UniversitySuwonKorea
  6. 6.Department of PharmacyKyungsung UniversityBusanKorea

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