Archives of Pharmacal Research

, Volume 33, Issue 10, pp 1679–1683

The regulation of blood glucose level in physical and emotional stress models: Possible involvement of adrenergic and glucocorticoid systems

  • Yun-Beom Sim
  • Soo-Hyun Park
  • Yu-Jung Kang
  • Seon-Mi Kim
  • Jin-Koo Lee
  • Jun-Sub Jung
  • Hong-Won Suh
Research Articles Drug Actions

DOI: 10.1007/s12272-010-1018-3

Cite this article as:
Sim, Y., Park, S., Kang, Y. et al. Arch. Pharm. Res. (2010) 33: 1679. doi:10.1007/s12272-010-1018-3

Abstract

This study was done to determine the effect of stress on blood glucose regulation in ICR mice. The stress was induced by the electrical foot shock-witness model. Blood glucose level was found to be increased in the electrical foot shock-induced physical stress group. Furthermore, the blood glucose levels were also elevated in the emotional stress group in both physical and emotional stress groups. The blood glucose level reached maximum 30 min after stress stimulation and returned to normal level 2 h after stress stimulation in both physical and emotional stress groups. Subsequently, we observed that intraperitoneal injection of phentolamine (an α1-adrenergic receptor antagonist), yohimbine (an α2-adrenergic receptor antagonist) or RU486 (a glucocorticoid receptor blocker) significantly inhibited blood glucose level induced by both physical and emotional stress. The results of our study suggest that physical and emotional stress increases blood glucose level via activation of adrenergic and glucocorticoid system.

Key words

Emotional stressPhysical stressBlood glucoseAdrenergicGlucocorticoid

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Yun-Beom Sim
    • 1
  • Soo-Hyun Park
    • 1
  • Yu-Jung Kang
    • 1
  • Seon-Mi Kim
    • 1
  • Jin-Koo Lee
    • 1
  • Jun-Sub Jung
    • 1
  • Hong-Won Suh
    • 1
    • 2
  1. 1.Department of Pharmacology, Institute of Natural Medicine, College of MedicineHallym UniversityChuncheonKorea
  2. 2.Department of Pharmacology, College of MedicineHallym UniversityChuncheonKorea