The regulation of blood glucose level in physical and emotional stress models: Possible involvement of adrenergic and glucocorticoid systems
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This study was done to determine the effect of stress on blood glucose regulation in ICR mice. The stress was induced by the electrical foot shock-witness model. Blood glucose level was found to be increased in the electrical foot shock-induced physical stress group. Furthermore, the blood glucose levels were also elevated in the emotional stress group in both physical and emotional stress groups. The blood glucose level reached maximum 30 min after stress stimulation and returned to normal level 2 h after stress stimulation in both physical and emotional stress groups. Subsequently, we observed that intraperitoneal injection of phentolamine (an α1-adrenergic receptor antagonist), yohimbine (an α2-adrenergic receptor antagonist) or RU486 (a glucocorticoid receptor blocker) significantly inhibited blood glucose level induced by both physical and emotional stress. The results of our study suggest that physical and emotional stress increases blood glucose level via activation of adrenergic and glucocorticoid system.
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- The regulation of blood glucose level in physical and emotional stress models: Possible involvement of adrenergic and glucocorticoid systems
Archives of Pharmacal Research
Volume 33, Issue 10 , pp 1679-1683
- Cover Date
- Print ISSN
- Online ISSN
- Pharmaceutical Society of Korea
- Additional Links
- Emotional stress
- Physical stress
- Blood glucose
- Industry Sectors
- Author Affiliations
- 1. Department of Pharmacology, Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon, 200-702, Korea
- 2. Department of Pharmacology, College of Medicine, Hallym University, Chuncheon, 200-702, Korea