Review

Archives of Pharmacal Research

, Volume 33, Issue 10, pp 1539-1556

Inflammation and Alzheimer’s disease

  • Young-Jung LeeAffiliated withCollege of Pharamcy and Medical Research Center, Chungbuk National University
  • , Sang Bae HanAffiliated withCollege of Pharamcy and Medical Research Center, Chungbuk National University
  • , Sang-Yoon NamAffiliated withResearch Institute of Veterinary Medicine, Chungbuk National University
  • , Ki-Wan OhAffiliated withCollege of Pharamcy and Medical Research Center, Chungbuk National University
  • , Jin Tae HongAffiliated withCollege of Pharamcy and Medical Research Center, Chungbuk National UniversityCollege of Pharmacy, Chungbuk National University Email author 

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. Although the pathophysiologic mechanism is not fully established, inflammation appears to be involved. Neuroinflammation has been known to play a critical role in the pathogenesis of chronic neurodegenerative disease in general, and in AD in particular. Numerous studies show the presence of a number of markers of inflammation in the AD brain: elevated inflammatory cytokines and chemokines, and accumulation of activated microglia in the damaged regions. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs suppresses the progression of AD and delays its onset, suggesting that there is a close correlation between neuroinflammation and AD pathogenesis. The aim of this review is (1) to assess the association between neuroinflammation and AD through discussion of a variety of experimental and clinical studies on AD and (2) to review treatment strategies designed to treat or prevent AD.

Key words

Alzheimer’s disease Inflammation Neuroinflammation