Archives of Pharmacal Research

, Volume 33, Issue 10, pp 1539–1556

Inflammation and Alzheimer’s disease

Authors

  • Young-Jung Lee
    • College of Pharamcy and Medical Research CenterChungbuk National University
  • Sang Bae Han
    • College of Pharamcy and Medical Research CenterChungbuk National University
  • Sang-Yoon Nam
    • Research Institute of Veterinary MedicineChungbuk National University
  • Ki-Wan Oh
    • College of Pharamcy and Medical Research CenterChungbuk National University
    • College of Pharamcy and Medical Research CenterChungbuk National University
    • College of PharmacyChungbuk National University
Review

DOI: 10.1007/s12272-010-1006-7

Cite this article as:
Lee, Y., Han, S.B., Nam, S. et al. Arch. Pharm. Res. (2010) 33: 1539. doi:10.1007/s12272-010-1006-7

Abstract

Alzheimer’s disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. Although the pathophysiologic mechanism is not fully established, inflammation appears to be involved. Neuroinflammation has been known to play a critical role in the pathogenesis of chronic neurodegenerative disease in general, and in AD in particular. Numerous studies show the presence of a number of markers of inflammation in the AD brain: elevated inflammatory cytokines and chemokines, and accumulation of activated microglia in the damaged regions. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs suppresses the progression of AD and delays its onset, suggesting that there is a close correlation between neuroinflammation and AD pathogenesis. The aim of this review is (1) to assess the association between neuroinflammation and AD through discussion of a variety of experimental and clinical studies on AD and (2) to review treatment strategies designed to treat or prevent AD.

Key words

Alzheimer’s diseaseInflammationNeuroinflammation

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010