Archives of Pharmacal Research

, Volume 33, Issue 6, pp 875–880

Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on advanced glycation end products and rat lens aldose reductase in vitro

  • Dae Sik Jang
  • Yun Mi Lee
  • Il Ha Jeong
  • Jin Sook Kim
Research Articles Drug Discovery and Development

DOI: 10.1007/s12272-010-0610-x

Cite this article as:
Jang, D.S., Lee, Y.M., Jeong, I.H. et al. Arch. Pharm. Res. (2010) 33: 875. doi:10.1007/s12272-010-0610-x

Abstract

In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-β-d-glucopyranoside (2), apigenin-7-O-(6″-O-acetyl)-β-d-glucopyranoside (3), luteolin (4), luteolin-7-O-β-d-glucopyranoside (5), luteolin-7-O-(6″-O-acetyl)-β-d-glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-β-d-glucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), β-sitosterol glucoside (14), and α-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.

Key words

Platycodon grandiflorum Campanulaceae Advanced glycation end products (AGEs) Rat lens aldose reductase (RLAR) Diabetic complications 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Dae Sik Jang
    • 1
  • Yun Mi Lee
    • 1
  • Il Ha Jeong
    • 1
  • Jin Sook Kim
    • 1
  1. 1.Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated ResearchKorea Institute of Oriental Medicine (KIOM)DaejeonKorea

Personalised recommendations