Archives of Pharmacal Research

, Volume 33, Issue 5, pp 787–792

Genistein inhibits Vibrio vulnificus adhesion and cytotoxicity to HeLa cells

Authors

  • Dool-Ri Oh
    • Department of Oriental Medicine MaterialsDongshin University
  • Jong Ro Kim
    • Korea INS Pharm Inc.
    • Department of Oriental Medicine MaterialsDongshin University
Research Articles Drug Actions

DOI: 10.1007/s12272-010-0520-y

Cite this article as:
Oh, D., Kim, J.R. & Kim, Y.R. Arch. Pharm. Res. (2010) 33: 787. doi:10.1007/s12272-010-0520-y

Abstract

Vibrio vulnificus (V. vulnificus) is a useful model for bacterial septicemia as the bacterial infection generates a wide pathogenic spectrum in addition to a high mortality rate. This study was aimed at investigating the effects of genistein on the growth, cytotoxicity, adhesion, and the mouse mortality caused by V. vulnificus. The results of our study indicated that genistein (50 or 100 mg/L) effectively minimized the morphologic damages and inhibited acute death of HeLa cells by V. vulnificus. Strikingly, genistein significantly inhibited the adhesion of V. vulnificus to HeLa cells. This report confirmed that genistein showed bacteriostatic activity against V. vulnificus, but it did not exhibit any bactericidal activity. Nevertheless, genistein (20 mg/kg) effectively decreased CD-1 mice mortality caused by V. vulnificus infection.

Key words

GenisteinV. vulnificusCytotoxicityAdhesionAntibacterial Activity

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010