The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts
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- Lee, SY., Kim, MR., Choi, H.S. et al. Arch. Pharm. Res. (2009) 32: 1433. doi:10.1007/s12272-009-2013-4
The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.