Archives of Pharmacal Research

, 32:1433

The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts

  • Song-Yi Lee
  • Mi-Ran Kim
  • Hong Seok Choi
  • Hyung-In Moon
  • Jin Ho Chung
  • Dong Gun Lee
  • Eun-Rhan Woo
Research Articles Drug Actions

DOI: 10.1007/s12272-009-2013-4

Cite this article as:
Lee, SY., Kim, MR., Choi, H.S. et al. Arch. Pharm. Res. (2009) 32: 1433. doi:10.1007/s12272-009-2013-4

Abstract

The dried rhizomes of Curculigo orchioides G. yielded two phenolic glycosides, curculigoside (1), orcinol-β-D-glucoside (4), and two cycloartane saponins, curculigosaponin G (2), curculigosaponin I (3). The structures were determined using spectroscopic methods. Among these isolates, compound 1 exhibited potent inhibitory activity against matrix metalloproteinase-1 in cultured human skin fibroblasts. In addition, it increased the level of Bcl-2 protein expression and decreased the level of Bax protein expression. Compound 4 was isolated from this plant for the first time.

Key words

Curculigo orchioides G. Amaryllidaceae Phenolic glycoside Curculigoside Cycloartane saponin Matrix metalloproteinase-1 Type-1 procollagen 

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2009

Authors and Affiliations

  • Song-Yi Lee
    • 1
  • Mi-Ran Kim
    • 1
  • Hong Seok Choi
    • 1
  • Hyung-In Moon
    • 2
  • Jin Ho Chung
    • 2
  • Dong Gun Lee
    • 3
  • Eun-Rhan Woo
    • 1
  1. 1.College of PharmacyChosun UniversityGwangjuKorea
  2. 2.Department of Dermatology, Seoul National University College of Medicine, and Clinical research InstituteSeoul National University HosipitalSeoulKorea
  3. 3.School of Life Sciences and Biotechnology, College of Natural SciencesKyungpook National UniversityDaeguKorea

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