Archives of Pharmacal Research

, Volume 32, Issue 10, pp 1345–1349

Lignans from the fruits of the red pepper (Capsicum annuum L.) and their antioxidant effects

  • Dae-Young Lee
  • Do-Gyeong Lee
  • Jin-Gyeong Cho
  • Myun-Ho Bang
  • Ha-Na Lyu
  • Youn-Hyung Lee
  • Se-Young Kim
  • Nam-In Baek
Research Articles Drug Discovery and Development

DOI: 10.1007/s12272-009-2001-8

Cite this article as:
Lee, DY., Lee, DG., Cho, JG. et al. Arch. Pharm. Res. (2009) 32: 1345. doi:10.1007/s12272-009-2001-8

Abstract

The fruits of Capsicum annuum were extracted using 80% aqueous MeOH, and fractionated using EtOAc and water. Repeated column chromatography using silica gel, octadecyl silica gel, and Sephadex LH-20 for the EtOAc fraction led to the isolation of a new lignan glycoside and a known one, icariside E5. From the results of spectroscopic data, including EIMS, FABMS, UV, IR, 1H and 13C-NMR, DEPT, and 2D-NMR (COSY, HSQC, HMBC), the chemical structure of the new lignan glycoside was determined as (8R)-isodehydrodiconiferyl alcohol-4′-O-(6″-vanilloyl)-β-D-glucopyranoside named vanilloylicariside E5. All isolated compounds were tested for antioxidant activities using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Icariside E5 (2) and (8R)-Isodehydrodiconiferyl alcohol (3) exhibited a strong scavenging effect on DPPH (2: IC50=42.1 µM, 3: IC50=4.5 µM).

Key words

Capsicum annuum L.Vanilloylicariside E5Icariside E5(8R)- Isodehydrodiconiferyl alcoholAntioxidant activityDPPH

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2009

Authors and Affiliations

  • Dae-Young Lee
    • 1
  • Do-Gyeong Lee
    • 1
  • Jin-Gyeong Cho
    • 1
  • Myun-Ho Bang
    • 2
  • Ha-Na Lyu
    • 1
  • Youn-Hyung Lee
    • 3
  • Se-Young Kim
    • 1
  • Nam-In Baek
    • 1
    • 4
  1. 1.Graduate School of Biotechnology and Department of Oriental Medicinal Materials & ProcessingKyung Hee UniversityYonginKorea
  2. 2.Skin Biotechnology CenterKyung Hee University Gyeonggi BiocenterSuwonKorea
  3. 3.Department of Horticultural BiotechnologyKyung Hee UniversityYonginKorea
  4. 4.Graduate School of BiotechnologyKyung Hee UniversityYong-InKorea