Research Articles Drug Actions

Archives of Pharmacal Research

, Volume 32, Issue 6, pp 907-913

First online:

Effect of coenzyme Q10 on cutaneous healing in skin-incised mice

  • Bang Shil ChoiAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Ho Sun SongAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Hee Rae KimAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Tae Wook ParkAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Tae Doo KimAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Bong Jae ChoAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Chang Jong KimAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University
  • , Sang Soo SimAffiliated withDepartment of Pathophysiology, College of Pharmacy, Chung-Ang University Email author 

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Abstract

Coenzyme Q10 (CoQ10) is a biosynthesized quinone with 10 isoprene side chains in humans. To investigate the anti-inflammatory and wound healing effect of CoQ10, we performed in vivo and in vitro experiments. In vivo studies, there were 3 groups; Naive (without skin incision), Control (with skin incision) and CoQ10 (100 mg/kg treatment with skin incision). Collagen-like polymer (CLP) level of CoQ10 group was increased significantly compared to the control group (p<0.05). Also, CoQ10 group showed significant inhibition on myeloperoxidase (MPO) and PLA2 level compared to the control group (p<0.05). These data show that CoQ10 may have an anti-inflammatory and a wound healing effect. CoQ10 showed significant antioxidant activity in vivo on malondialdehyde (MDA) and superoxide dismutase (SOD) levels compared to the control group (p<0.05). Although CoQ10 did not show antioxidant activity in cell free system of DPPH radical scavenge, it had a potent antioxidant activity in cell culture system of both silica- and zymosan-induced reactive oxygen species generation using Raw 264.7 cells. This result may be associated with the conversion of CoQ10 to the reduced form (CoQ10H2) in the presence of some kinds of intracellular reducing agents. In conclusion, it is considered that CoQ10 appears to have a cutaneous healing effect in vivo, which may be related to the secondary action of CoQ10.

Key words

CoQ10 Antioxidant Collagen-like polymer Cutaneous healing