Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction
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Rosa rugosa is a species of rose native to eastern Asia. The root of R. rugosa has been used to treat diabetes mellitus, pain and chronic inflammatory disease, and a R. rugosa petal extract has a strong anti-oxidant effect. In the present study, we examined if solvent fractions from white rose petal extract (WRPE) had any anti-allergic or anti-atopic effects not previously reported. WRPE and butanol and hexane fractions effectively reduced systemic anaphylactic reactions and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis in mice, with the greatest inhibition observed for the hexane fraction. In addition, a significant reduction of scratching behavior by mice after histamine injection suggested this fraction’s potential anti-allergic effect. At the cell level, the hexane fraction markedly inhibited β-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-γ and interleukin-4 cytokines produced by T helper cells (type 1 and 2). These results strongly support that the hexane fraction may have an effect on atopic dermatitis, as these 2 cell types play central roles in the pathogenesis of atopic dermatitis. In conclusion, these results suggest that either the hexane fraction or one of its components may be beneficial for the treatment of allergic diseases, including atopic dermatitis.
- Back, O., Scheynius, A., and Johansson, S. G. O., Ketoconazole in atopic dermatitis: therapeutic response in correlated with decrease in serum IgE. Arch. Dematol. Res., 287, 448–451 (1995). CrossRef
- Bornhove, E. C., Burgdorf, W. H., and Wollenberg, A., Immunomodulatory macrolactams for topical treatment of inflammatory skin diseases. Curr. Opin. Investig. Drugs, 3, 708–712 (2002).
- Cho, E. J., Yokozawa, T., Rhyu, D. Y., Kim, S. L., Shibahara, N., and Park, J. C., Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrylhydrazyl radical. Phytomedicine, 10, 544–551 (2003a). CrossRef
- Cho, E. J., Yokozawa, T., Rhyu, D. Y., Kim, H. Y., Shibahara, N., and Park, J. C., The inhibitory effects of 12 medicinal plants and their components on lipid peroxidation. Am. J. Chin. Med., 31, 907–917 (2003b). CrossRef
- Galli, S. J., Tsai, M., and Piliponsky, A. M. The development of allergic inflammation. Nature, 454, 445–454 (2008). CrossRef
- Grewe, M., Gyufko, K., Schopf, E., and Krutmann, J., Lesional expression of interferon-γ in atopic eczema. Lancet, 343, 25–26 (1994). CrossRef
- Hannan, J. M. A., Marenah, L., Ali, L., Rokeya, B., Flatt, P. R., and Abdel-Wahab, Y. H. A., Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatics β-cells. J. Endocrinol., 189, 127–136 (2006). CrossRef
- Hatano, T., Ogawa, N., Yasuhara, T., and Okuda, T., Tannins of rosaceous plants. VIII. Hydrolyzable tannin monomer having a valenoyl group from flower petals of Rosa rugosa Thunb. Chem. Pharm. Bull., 38, 3308–3313 (1990).
- Illustrated Book of Health for Longenity. Kyohaksa, Seoul, pp. 428 (2003).
- Inagaki, N., Nagao, M., Igeta, K., Kawasaki, H., Kim, J. F., and Nagai, H., Scratching behavior in various strains of mice. Skin Pharmacol. Appl. Skin. Physiol., 14, 87–96 (2001).
- Inagaki, N., Nakamura, N., Nagao, M., Musoh, K., Kawasaki, H., and Nagai, H., Participation of histamine H1 and H2 receptors in passive cutaneous anaphylaxis-induced scratching behaviorin ICR mice. Eur. J. Pharmacol., 367, 361–371 (1999). CrossRef
- Incorvaia, C., Frati, F., Verna, N., Alo, S. D., Motolese, A., and Pucci, S., Allergy and the skin. Clin. Exp. Immunol., 153, S27–29 (2008). CrossRef
- Kamijo, M., Kanazawa, T., Funaki, M., Nishizawa, M., and Yamagishi, T., Effects of Rosa rugosa petal on intestinal bacteria. Biosci. Biotechnol. Biochem., 72, 773–777 (2008). CrossRef
- Kim, S. H., Choi, C. H., Kim, S. Y., Eun, J. S., and Shin, T. Y., Anti-allergic effects of Arthmisia iwayomogi on mast cell-mediated allergy model. Exp. Biol. Med., 230, 82–88 (2005).
- Kwon, S. C., Shin, S., Jeon, J. H., Park, D., Jang., M. J., Kim, J. J., Kim, C. H., Jeong, J. H., and Kim, Y. B., Anti-allergic effects of rose petal extract and Ganoderma lucidum culture on mast cell-mediated allergy model. Lab. Anim. Res., 24, 93–97 (2008).
- Leung, D. Y. M., Boguniewicz, M., Howell, M. D., Nomura, I., and Hamid, Q. A., New insight into atopic dermatitis. J. Clin. Invest., 113, 651–657 (2004).
- Li, G. Z., Chai, O. H., Lee, M. S., Han, E. H., Kim, H. T., and Song, C. H., Inhibitory effects of Houttuynia cordata water extract on anaphylactic reaction and mast cell activation. Biol. Pharm. Bull., 28, 1864–1868 (2005). CrossRef
- Novak, N., Bieber, T, and Leung, D. Y. M., Immune mechanisms leading to atopic dermatitis. J. Allergy. Clin. Immunol., 112, S128–139 (2003). CrossRef
- Oettgen, H. C. and Geha, R. S., IgE in asthma and atopy: cellular and molecular connections. J. Clin. Invest., 104, 829–835 (1999). CrossRef
- Shin, T. Y., Kim, S. H., Suk, K., Ha, J. H., Kim, I., Lee, M. G., Jun, C. D., Kim, S. Y., Lim, J. P., Eun, J. S., Shin, H. Y., and Kim, H. M., Anti-allergic effects of Lycopus lucidus on mast cell-mediated allergy model. Toxicol. Appl. Pharmacol., 209, 255–262 (2005). CrossRef
- Sugimoto, Y., Umakoshi, K., Nojiri, N., and Kamei, C., Effects of histamine H1 receptor antagonists on compound 48/80-induced scratching behavior in mice. Eur. J. Pharmacol., 351, 1–5 (1998). CrossRef
- Tengvall Linder, M., Johansson, C., and Zargari, A., Detection of Pityrosporum orbiculare reactive T cells from skin and blood in atopic dermatitis and characterisation of their cytokine profiles. Clin. Exp. Allergy, 26, 1286–1297 (1996). CrossRef
- Wollenberg, A., Reitamo, S., Atzori, F., Lahfa, M., Ruzicka, T., Healy, E., Giannetti, A., Bieber, T., Vyas, J., and Deleuran, M., Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. Allergy, 63, 742–750 (2008). CrossRef
- Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction
Archives of Pharmacal Research
Volume 32, Issue 6 , pp 823-830
- Cover Date
- Print ISSN
- Online ISSN
- Pharmaceutical Society of Korea
- Additional Links
- Atopic dermatitis
- Industry Sectors
- Author Affiliations
- 1. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, 361-763, Korea
- 2. Chamsunjin Total Food Co., Ltd., Jincheon, 365-801, Korea
- 3. Division of Food and Biotechnology, Chungju National University, Chungju, 380-702, Korea
- 4. Environmental Toxico-Genomic & Proteomic Center, College of Medicine, Korea University, Seoul, 136-701, Korea
- 5. Daejeon University, Daejeon, 300-716, Korea
- 6. Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, 361-763, Korea