Archives of Pharmacal Research

, Volume 32, Issue 5, pp 767–772

Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution

  • Young-Joon Park
  • Ram Kwon
  • Qi Zhe Quan
  • Dong Hoon Oh
  • Jong Oh Kim
  • Ma Ro Hwang
  • Yoon Bon Koo
  • Jong Soo Woo
  • Chul Soon Yong
  • Han-Gon Choi
Research Articles Drug Actions

DOI: 10.1007/s12272-009-1516-3

Cite this article as:
Park, Y., Kwon, R., Quan, Q.Z. et al. Arch. Pharm. Res. (2009) 32: 767. doi:10.1007/s12272-009-1516-3

Abstract

To develop a novel ibuprofen-loaded solid dispersion with enhanced bioavailability, various ibuprofen-loaded solid dispersions were prepared with water, HPMC and poloxamer. The effect of HPMC and poloxamer on aqueous solubility of ibuprofen was investigated. The dissolution and bioavailability of solid dispersion in rats were then evaluated compared to ibuprofen powder. When the amount of carrier increased with a decreased in HPMC/poloxamer ratio, the aqueous solubility of ibuprofen was elevated. The solid dispersion composed of ibuprofen/HPMC/poloxamer at the weight ratio of 10:3:2 improved the drug solubility approximately 4 fold. It gave significantly higher initial plasma concentration, AUC and Cmax of drug than did ibuprofen powder in rats. The solid dispersion improved the bioavailability of drug about 4-fold compared to ibuprofen powder. Thus, this ibuprofen-loaded solid dispersion with water, HPMC and poloxamer was a more effective oral dosage form for improving the bioavailability of poor water-soluble ibuprofen.

Key words

Solid dispersionIbuprofenSolubilityPharmacokinetics

Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  • Young-Joon Park
    • 2
  • Ram Kwon
    • 1
  • Qi Zhe Quan
    • 3
  • Dong Hoon Oh
    • 1
  • Jong Oh Kim
    • 1
  • Ma Ro Hwang
    • 1
  • Yoon Bon Koo
    • 2
  • Jong Soo Woo
    • 1
  • Chul Soon Yong
    • 2
  • Han-Gon Choi
    • 1
  1. 1.College of PharmacyYeungnam UniversityGyongsanKorea
  2. 2.Research CenterSamil Pharmaceutical Co. Ltd.AnsanKorea
  3. 3.Biochemical Engineering CollegeBeijing Union UniversityBeijingChina