Archives of Pharmacal Research

, Volume 32, Issue 5, pp 655–659

Antibacterial activity of two phloroglucinols, flavaspidic acids AB and PB, from Dryopteris crassirhizoma

Research Articles Drug Discovery and Development

DOI: 10.1007/s12272-009-1502-9

Cite this article as:
Lee, H.B., Kim, J.C. & Lee, S.M. Arch. Pharm. Res. (2009) 32: 655. doi:10.1007/s12272-009-1502-9


The antimicrobial effect of solvent extracts from the rhizome of a thick-stemmed wood fern (Dryopteris crassirhizoma) was evaluated and its phloroglucinol components, flavaspidic acids PB and AB. Flavaspidic acids PB and AB were isolated from the D. crassirhizoma rhizomes by methanol extraction, followed by silica gel and Sephadex LH-20 column chromatography. The chemical structures were characterized by spectral techniques, including ESI-MS, UV, 1H- and 13C-NMR spectrum analysis. When the antimicrobial activity of the extracts and compounds was tested by the paper disc method, the extracts and compounds were highly active against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus KCTC 1928 (a MRSA bacterium), Streptococcus mutans and Bacillus subtilis. The extracts and compounds were not active against fungi and chlorella. Our study revealed that the antibacterial activity of samples from D. crassirhizoma was mainly related to the flavaspidic acids.

Key words

Antibacterial activity Phloroglucinols Flavaspidic acids Dryopteris crassirhizoma 

Copyright information

© The Pharmaceutical Society of Korea 2009

Authors and Affiliations

  1. 1.Division of Applied Bioscience and Biotechnology, College of Agriculture and Life SciencesChonnam National UniversityGwangjuKorea
  2. 2.Korea Research Institute of Chemistry & TechnologyDaejeonKorea
  3. 3.KT & G Central Research InstituteDaejeonKorea

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