Archives of Pharmacal Research

, Volume 32, Issue 4, pp 565–573

Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks

Authors

  • Qiu-hai Qian
    • Pharmic DepartmentMedical College of Qingdao University
    • Affiliated Hospital of Shandong University of Traditional Chinese Medicine
    • Pharmic DepartmentMedical College of Qingdao University
  • Yao-xia Wang
    • Pharmic DepartmentMedical College of Qingdao University
  • Zhi-hong Yang
    • Pharmic DepartmentMedical College of Qingdao University
  • Zhan-tao Liu
    • Pharmic DepartmentMedical College of Qingdao University
  • Wen-hui Chen
    • Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Article

DOI: 10.1007/s12272-009-1413-9

Cite this article as:
Qian, Q., Yue, W., Wang, Y. et al. Arch. Pharm. Res. (2009) 32: 565. doi:10.1007/s12272-009-1413-9

Abstract

Objective

To investigate the antiemetic effect of gingerol and its multi-targets effective mechanism on 5-hydroxytryptamine (5-HT), dopamine (DA) and substance P (SP). The antiemetic effect of gingerol was investigated on a vomiting model of mink induced by cisplatin (7.5 mg · kg−1, i.p.) in 6 h observation. The levels of 5-HT, DA and distribution of substance P in the area postrema and ileum were measured by high performance liquid chromatography (HPLC) and immunohistochemistry respectively. The frequency of cisplatin induced retching and vomiting was significantly reduced by pretreatment with gingerol in a dose-dependent manner (P<0.05). Cisplatin produced a significant increase in 5-HT and DA levels in the area postrema and ileum of minks (P<0.05), and this increase was significantly inhibited by gingerol in a dose-dependent manner (P<0.05). Substance P-immunoreactive was mainly situated in the mucosa and submucosa of ileum as well as in the neurons of area postrema, and gingerol markedly suppressed the increase immunoreactivity of substance P induced by cisplatin in a dose-dependent manner (P<0.05). Gingerol has good activity against cisplatin-induced emesis in minks possibly by inhibiting central or peripheral increase of 5-HT, DA and substance P.

Key words

Gingerol Vomiting Mink Cisplatin 5-HT Dopamine Substance P

Copyright information

© The Pharmaceutical Society of Korea 2009