Article

Archives of Pharmacal Research

, Volume 31, Issue 1, pp 83-87

trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo

  • Sunhee ShinAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Jeong Hee JeonAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Dongsun ParkAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Min-Jung JangAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Jae Hong ChoiAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Bong-Ho ChoiAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Seong Soo JooAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University
  • , Sang-Seop NahmAffiliated withCollege of Veterinary Medicine, Konkuk University
  • , Jong-Choon KimAffiliated withCollege of Veterinary Medicine, Chonnam National University
    • , Yun-Bae KimAffiliated withCollege of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University Email author 

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Abstract

We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5×10−5 M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.

Key words

Resveratrol Corpus cavernosum relaxation Testosterone Sperm counts and motility