Date: 26 Mar 2008
trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5×10−5 M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.
Andersson, K. E. and Wagner, G, Physiology of penile erection. Physiol. Rev., 75, 191–236 (1995).PubMed
Chen, C. K. and Pace-Asciak, C. R., Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmac., 27, 363–366 (1996).
Fouad, R., Vivien, K., and Ronald, S., Male sexual function and its disorders: physiology, pathophysiology, clinical investigation, and treatment. Endocr. Rev., 22, 342–388 (1993).
Jeon, J. H., Shin, S., Park, D., Jang, J. Y., Choi, B., Kang, J.-K., Hwang, S.-Y., and Kim, J.-C., Kim, B.-Y., Kim, M. R., and Kim, Y.-B., Fermentation filtrates of Rubus coreanus relax the corpus cavernosum and increase the sperm count and motility. J. Med. Food in press (2007).
Jouannet, P., Wang, C., Eustache, F., Kold-Jensen, T., and Auger, J., Semen quality and male reproductive health: the controversy about human sperm concentration decline. Acta Pathol. Microbiol. Immunol. Scand., 109, 333–344 (2001).
Juan, M. E., Gonzalez-Pons, E., Munuera, T., Ballester, J., Rodriguez-Gil, J. E., and Planas, J. M., trans-Resveratrol, a naturall antioxidant from grapes, increases sperm output in healthy rats. J. Nutr., 135, 757–760 (2005).PubMed
Kleinert, H., Wallerath, T., Euchenhofer, C., Ihrig-Biedert, I., Li, H., and Förstermann, U., Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension, 31, 582–588 (1998).PubMed
Li, H., Wallerath, T., and Förstermann, U., Physiological mechanisms regulating the expression of endothelial-type NO synthase. Nitric oxide Biol. Chem., 7, 103–118 (2002).CrossRef
Padama-Nathan, H., Eardly, I., Kloner, R. A., Laties, A. M., and Montorsi, F., A 4 year update on the safety of sildenafil citrate (Viagra). Urology, 60(suppl. 2B), 67–90 (2002).CrossRef
Sinclair, S., Male fertility: nutritional and environmental considerations. Altern. Med. Rev., 5, 28–38 (2005).
Wallerath, T., Poleo, D., Li, H., and Forstermann, U., Red wine increase the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J. Am. College Cardiol., 41, 479–478 (2003).
- trans-resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo
Archives of Pharmacal Research
Volume 31, Issue 1 , pp 83-87
- Cover Date
- Print ISSN
- Online ISSN
- Pharmaceutical Society of Korea
- Additional Links
- Corpus cavernosum relaxation
- Sperm counts and motility
- Industry Sectors
- Author Affiliations
- 3. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, 410 Seongbongro, Heungdeok-gu, Cheongju, Chungbuk, 361-763, Korea
- 1. College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Kwangjin-gu, Seoul, 143-701, Korea
- 2. College of Veterinary Medicine, Chonnam National University, 333 Yongbongro (Yongbong-dong), Buk-gu, Gwangju, 500-757, Korea