Research Articles Drug Discovery

Archives of Pharmacal Research

, Volume 31, Issue 8, pp 970-972

First online:

A new chromone glycoside from Rhododendron spinuliferum

  • Gang ChenAffiliated withSchool of Pharmacy, Shanghai Jiaotong UniversitySchool of Lifescience and Pharmaceutical Engineering, NanJing University of Technology
  • , Hui Zi JinAffiliated withSchool of Pharmacy, Shanghai Jiaotong University Email author 
  • , Xue Feng LiAffiliated withJiangXi University of Traditional Chinese Medicine, Key Laboratory of Modern Chinese Preparation, Ministry of Education
  • , Qi ZhangAffiliated withSchool of Lifescience and Pharmaceutical Engineering, NanJing University of Technology
  • , Yun Heng ShenAffiliated withSchool of Pharmacy, Second Military University
  • , Shi Kai YanAffiliated withSchool of Pharmacy, Shanghai Jiaotong University
  • , Wei Dong ZhangAffiliated withSchool of Pharmacy, Shanghai Jiaotong UniversitySchool of Pharmacy, Second Military University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

A new chromone glycoside, 3,5,7-trihydroxylchromone-3-O-α-L-arabinopyranoside (1), together with quercetin (2), (+)-catechin (3), (−)-epi-catechin (4) were isolated from the aerial parts of Rhododendron spinuliferum. The structure of 1 was elucidated on the basis of spectroscopic and 2D-NMR spectral analysis. In addition, 1 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.

Key words

Rhododendron spinuliferum Chromone 3,5,7-Trihydroxylchromone-3-O-α-L-arabinopyranoside Nitric oxide (NO) production