Archives of Pharmacal Research

, 31:415

Cytotoxic components from the dried rhizomes of Zingiber officinaleRoscoe

Authors

  • Ju Sin Kim
    • College of PharmacyWoosuk University
  • Sa Im Lee
    • College of PharmacyWoosuk University
  • Hye Won Park
    • College of PharmacyWoosuk University
  • Jae Heon Yang
    • College of PharmacyWoosuk University
  • Tae-Yong Shin
    • College of PharmacyWoosuk University
  • Youn-Chul Kim
    • College of PharmacyWonkwang University
    • College of PharmacyWoosuk University
  • Nam-In Baek
    • Graduate School of Biotechnology & Plant Metabolism Research CenterKyungHee University
    • College of PharmacyWoosuk University
  • Sung-Hoon Kim
    • Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental MedicineKyungHee University
    • College of PharmacyWoosuk University
  • Sang Un Choi
    • Korea Research Institute of Chemical Technology
    • College of PharmacyWoosuk University
  • Byoung-Mog Kwon
    • Korea Research Institute of Bioscience and BiotechnologyKIST
    • College of PharmacyWoosuk University
  • Kang-Hyun Leem
    • College of Oriental MedicineSemyung University
    • College of PharmacyWoosuk University
  • Mun Yhung Jung
    • Department of Food Science and TechnologyWoosuk University
    • College of PharmacyWoosuk University
    • College of PharmacyWoosuk University
Article

DOI: 10.1007/s12272-001-1172-y

Cite this article as:
Kim, J.S., Lee, S.I., Park, H.W. et al. Arch. Pharm. Res. (2008) 31: 415. doi:10.1007/s12272-001-1172-y
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Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53-/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).

Key words

Zingiber officinaleZingiberaceaeGingerolShogaolCytotoxicityCell proliferation

Copyright information

© The Pharmaceutical Society of Korea 2008