Article

Archives of Pharmacal Research

, Volume 31, Issue 4, pp 415-418

Cytotoxic components from the dried rhizomes of Zingiber officinaleRoscoe

  • Ju Sin KimAffiliated withCollege of Pharmacy, Woosuk University
  • , Sa Im LeeAffiliated withCollege of Pharmacy, Woosuk University
  • , Hye Won ParkAffiliated withCollege of Pharmacy, Woosuk University
  • , Jae Heon YangAffiliated withCollege of Pharmacy, Woosuk University
  • , Tae-Yong ShinAffiliated withCollege of Pharmacy, Woosuk University
  • , Youn-Chul KimAffiliated withCollege of Pharmacy, Woosuk UniversityCollege of Pharmacy, Wonkwang University
  • , Nam-In BaekAffiliated withCollege of Pharmacy, Woosuk UniversityGraduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University
  • , Sung-Hoon KimAffiliated withCollege of Pharmacy, Woosuk UniversityLab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental Medicine, KyungHee University
  • , Sang Un ChoiAffiliated withCollege of Pharmacy, Woosuk UniversityKorea Research Institute of Chemical Technology
    • , Byoung-Mog KwonAffiliated withCollege of Pharmacy, Woosuk UniversityKorea Research Institute of Bioscience and Biotechnology, KIST
    • , Kang-Hyun LeemAffiliated withCollege of Pharmacy, Woosuk UniversityCollege of Oriental Medicine, Semyung University
    • , Mun Yhung JungAffiliated withCollege of Pharmacy, Woosuk UniversityDepartment of Food Science and Technology, Woosuk University
    • , Dae Keun KimAffiliated withCollege of Pharmacy, Woosuk University Email author 

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Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53-/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).

Key words

Zingiber officinale Zingiberaceae Gingerol Shogaol Cytotoxicity Cell proliferation