Cytotoxic components from the dried rhizomes of Zingiber officinaleRoscoe

  • Ju Sin Kim
  • Sa Im Lee
  • Hye Won Park
  • Jae Heon Yang
  • Tae-Yong Shin
  • Youn-Chul Kim
  • Nam-In Baek
  • Sung-Hoon Kim
  • Sang Un Choi
  • Byoung-Mog Kwon
  • Kang-Hyun Leem
  • Mun Yhung Jung
  • Dae Keun Kim
Article

DOI: 10.1007/s12272-001-1172-y

Cite this article as:
Kim, J.S., Lee, S.I., Park, H.W. et al. Arch. Pharm. Res. (2008) 31: 415. doi:10.1007/s12272-001-1172-y

Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53-/-, c-myc, K-ras) and C2 (genotype: p53-/-, c-myc, Akt), with ED50 values of 0.58 μM (C1) and 10.7 μM (C2).

Key words

Zingiber officinale Zingiberaceae Gingerol Shogaol Cytotoxicity Cell proliferation 

Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  • Ju Sin Kim
    • 1
  • Sa Im Lee
    • 1
  • Hye Won Park
    • 1
  • Jae Heon Yang
    • 1
  • Tae-Yong Shin
    • 1
  • Youn-Chul Kim
    • 2
    • 1
  • Nam-In Baek
    • 3
    • 1
  • Sung-Hoon Kim
    • 4
    • 1
  • Sang Un Choi
    • 5
    • 1
  • Byoung-Mog Kwon
    • 6
    • 1
  • Kang-Hyun Leem
    • 7
    • 1
  • Mun Yhung Jung
    • 8
    • 1
  • Dae Keun Kim
    • 1
  1. 1.College of PharmacyWoosuk UniversitySamryeKorea
  2. 2.College of PharmacyWonkwang UniversityIksanKorea
  3. 3.Graduate School of Biotechnology & Plant Metabolism Research CenterKyungHee UniversitySuwonKorea
  4. 4.Lab. of Angiogenesis and Chemoprevention, Department of Oriental Pathology, College of Oriental MedicineKyungHee UniversitySeoulKorea
  5. 5.Korea Research Institute of Chemical TechnologyTaejeonKorea
  6. 6.Korea Research Institute of Bioscience and BiotechnologyKISTTaejeonKorea
  7. 7.College of Oriental MedicineSemyung UniversityJechonKorea
  8. 8.Department of Food Science and TechnologyWoosuk UniversitySamryeKorea

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