BIOspektrum

, Volume 20, Issue 2, pp 163–166

Transkriptom-Sequenzierung in der Alternsforschung

Biologie des Alterns
  • Marco Groth
  • Kathrin Reichwald
  • Karol Szafranski
  • Stefan Taudien
  • Matthias Platzer
Wissenschaft · Special: Next Generation Sequencing

DOI: 10.1007/s12268-014-0423-4

Cite this article as:
Groth, M., Reichwald, K., Szafranski, K. et al. Biospektrum (2014) 20: 163. doi:10.1007/s12268-014-0423-4
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Abstract

With the advent of next-generation sequencing technologies transcriptome sequencing (RNA-seq) became widely used to study the genetic background of ageing processes and related diseases. We describe the power of this method in the study of two novel age research model organisms, the short-lived killifish Nothobranchius furzeri and the long-lived naked mole rat Heterocephalus glaber. A third example illustrates the utility of RNA-seq in a multispecies approach elucidating the role of mild stress in healthy ageing.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Marco Groth
    • 1
  • Kathrin Reichwald
    • 1
  • Karol Szafranski
    • 1
  • Stefan Taudien
    • 1
    • 2
  • Matthias Platzer
    • 1
  1. 1.Leibniz-Institut für AltersforschungFritz-Lipmann-Institut (FLI)JenaGermany
  2. 2.Leibniz-Institut für AltersforschungFritz-Lipmann-Institut (FLI)JenaGermany