Transkriptom-Sequenzierung in der Alternsforschung
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- Groth, M., Reichwald, K., Szafranski, K. et al. Biospektrum (2014) 20: 163. doi:10.1007/s12268-014-0423-4
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With the advent of next-generation sequencing technologies transcriptome sequencing (RNA-seq) became widely used to study the genetic background of ageing processes and related diseases. We describe the power of this method in the study of two novel age research model organisms, the short-lived killifish Nothobranchius furzeri and the long-lived naked mole rat Heterocephalus glaber. A third example illustrates the utility of RNA-seq in a multispecies approach elucidating the role of mild stress in healthy ageing.