Wissenschaft · Methoden Biosensoren

BIOspektrum

, Volume 19, Issue 7, pp 739-741

Transkriptionsregulatoren im Dienste der Biotechnologie

  • Regina MahrAffiliated withInstitut für Bio- und Geowissenschaften, IBG-1: Biotechnologie, Forschungszentrum Jülich
  • , Julia FrunzkeAffiliated withInstitut für Bio- und Geowissenschaften, IBG-1: Biotechnologie, Forschungszentrum JülichInstitut für Bio- und Geowissenschaften IBG1: Biotechnologie, Forschungszentrum Jülich Email author 

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Abstract

Microbes have evolved a variety of sensor devices for the intracellular detection of small molecules. This capability was recently harnessed for the construction of transcription factor-based biosensors translating the intracellular amino acid accumulation in Corynebacterium glutamicum into a fluorescent readout. These systems were successfully implemented in FACS high throughput screening approaches and allow the study of microbial populations at the single cell level.