, Volume 19, Issue 7, pp 739–741

Transkriptionsregulatoren im Dienste der Biotechnologie

Wissenschaft · Methoden Biosensoren

DOI: 10.1007/s12268-013-0385-y

Cite this article as:
Mahr, R. & Frunzke, J. Biospektrum (2013) 19: 739. doi:10.1007/s12268-013-0385-y


Microbes have evolved a variety of sensor devices for the intracellular detection of small molecules. This capability was recently harnessed for the construction of transcription factor-based biosensors translating the intracellular amino acid accumulation in Corynebacterium glutamicum into a fluorescent readout. These systems were successfully implemented in FACS high throughput screening approaches and allow the study of microbial populations at the single cell level.

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Institut für Bio- und Geowissenschaften, IBG-1: BiotechnologieForschungszentrum JülichJülichGermany
  2. 2.Institut für Bio- und Geowissenschaften IBG1: BiotechnologieForschungszentrum JülichJülichGermany