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TALEs — Proteine mit programmier — barer DNA-Bindespezifität

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  • Pflanzenpathogene
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BIOspektrum Aims and scope

Abstract

Plant-pathogenic xanthomonads have evolved TAL effectors (TALEs) as activators of plant genes to manipulate the host to their benefit. Cracking the code of TALE DNA-binding specificity revealed a simple one-to-one relationship between protein domains and DNA bases bound. This now allows the simple design of any desired DNA-binding specificity. Accordingly, TALEs and their nuclease derivatives have soared as biotechnology tools for gene control and genome engineering.

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Authors and Affiliations

  1. Institut für Biologie, Abteilung Pflanzengenetik, Universität Halle-Wittenberg, Halle, Germany

    Jana Streubel, Annekatrin Richter, Maik Reschke & Jens Boch

  2. Institut für Biologie Abteilung Pflanzengenetik, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 10, D-06120, Halle (Saale), Germany

    Jens Boch

Authors
  1. Jana Streubel
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  2. Annekatrin Richter
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  3. Maik Reschke
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  4. Jens Boch
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Corresponding author

Correspondence to Jens Boch.

Additional information

Annekatrin Richter, Maik Reschke und Jana Streubel (v. l. n. r.) Biologiestudium an der Martin-Luther-Universität Halle. Zurzeit Promotion in der Arbeitsgruppe von Jens Boch (ganz rechts).

Jens Boch 1987–1993 Biologiestudium an der Universität Marburg; dort 1996 Promotion am Lehrstuhl für Mikrobiologie. 1996–1997 Postdoc am Max-Planck-Institut für Terrestrische Mikrobiologie, Marburg. 1997–1999 Postdoc an der Washington University in St. Louis, MO, USA. Seit 1999 Leiter einer Nachwuchsgruppe in Halle. 2013 VAAM-Forschungspreis 2013.

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Streubel, J., Richter, A., Reschke, M. et al. TALEs — Proteine mit programmier — barer DNA-Bindespezifität. Biospektrum 19, 370–372 (2013). https://doi.org/10.1007/s12268-013-0322-0

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  • DOI: https://doi.org/10.1007/s12268-013-0322-0

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