Journal of Cardiovascular Translational Research

, Volume 6, Issue 5, pp 787–797

CXCR4+ and FLK-1+ Identify Circulating Cells Associated with Improved Cardiac Function in Patients Following Myocardial Infarction

  • Rahul Suresh
  • Anca Chiriac
  • Kashish Goel
  • Hector R. Villarraga
  • Francisco Lopez-Jimenez
  • Randal J. Thomas
  • Andre Terzic
  • Timothy J. Nelson
  • Carmen Perez-Terzic
Article

DOI: 10.1007/s12265-013-9502-z

Cite this article as:
Suresh, R., Chiriac, A., Goel, K. et al. J. of Cardiovasc. Trans. Res. (2013) 6: 787. doi:10.1007/s12265-013-9502-z

Abstract

The biomarkers CXCR4/FLK-1 select cardiac progenitors from a stem cell pool in experimental models. However, the translational value of these cells in human ischemic heart disease is unknown. Here, flow-cytometry identified CD45/CXCR4+/FLK-1+ cells in 30 individuals without ischemic heart disease and 33 first-time acute myocardial infarction (AMI) patients. AMI patients had higher CD45/CXCR4+/FLK-1+ cell-load at 48-h and 3- and 6-months post-AMI (p = 0.003,0.04,0.04, respectively) than controls. Cardiovascular risk factors and left ventricular (LV) ejection fraction were not associated with cell-load. 2D-speckle-tracking strain echocardiography assessment of LV systolic function showed improvement in longitudinal strain and dyssynchrony during follow-up associated with longitudinal increases in and higher 48-h post-AMI CD45/CXCR4+/FLK-1+ cell-load (r = −0.525, p = 0.025; r = −0.457, p = 0.029, respectively). In conclusion, CD45/CXCR4+/FLK-1+ cells are present in adult human circulation, increased in AMI and associated with improved LV systolic function. Thus, CD45/CXCR4+/FLK-1+ cells may provide a diagnostic tool to follow cardiac regenerative capacity and potentially serve as a prognostic marker in AMI.

Keywords

CXCR4FLK-1Cardiac progenitor cellsLongitudinal strainMyocardial infarction

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rahul Suresh
    • 1
  • Anca Chiriac
    • 2
  • Kashish Goel
    • 3
  • Hector R. Villarraga
    • 3
  • Francisco Lopez-Jimenez
    • 3
  • Randal J. Thomas
    • 3
  • Andre Terzic
    • 2
    • 3
    • 5
  • Timothy J. Nelson
    • 2
    • 4
    • 5
  • Carmen Perez-Terzic
    • 6
  1. 1.Mayo Medical SchoolCollege of MedicineRochesterUSA
  2. 2.Department of Molecular Pharmacology and Experimental TherapeuticsMayo ClinicRochesterUSA
  3. 3.Division of Cardiovascular Diseases, Department of MedicineMayo ClinicRochesterUSA
  4. 4.Division of General Internal Medicine and Transplant Center, Department of MedicineMayo ClinicRochesterUSA
  5. 5.Center for Regenerative MedicineMayo ClinicRochesterUSA
  6. 6.Department of Physical Medicine and RehabilitationMayo ClinicRochesterUSA