Article

Journal of Cardiovascular Translational Research

, Volume 6, Issue 6, pp 884-898

First online:

Circulating MicroRNAs as Novel Biomarkers for the Early Diagnosis of Acute Coronary Syndrome

  • J. C. DeddensAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
  • , J. M. ColijnAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
  • , M. I. F. J. OerlemansAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
  • , G. PasterkampAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
  • , S. A. ChamuleauAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht
  • , P. A. DoevendansAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center UtrechtNetherlands Heart Institute (ICIN)
  • , J. P. G. SluijterAffiliated withDepartment of Cardiology, Division Heart and Lungs, University Medical Center UtrechtNetherlands Heart Institute (ICIN) Email author 

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Abstract

Small non-coding microRNAs (miRNAs) are important physiological regulators of post-transcriptional gene expression. miRNAs not only reside in the cytoplasm but are also stably present in several extracellular compartments, including the circulation. For that reason, miRNAs are proposed as diagnostic biomarkers for various diseases. Early diagnosis of acute coronary syndrome (ACS), especially non-ST elevated myocardial infarction and unstable angina pectoris, is essential for optimal treatment outcome, and due to the ongoing need for additional identifiers, miRNAs are of special interest as biomarkers for ACS. This review highlights the nature and cellular release mechanisms of circulating miRNAs and therefore their potential role in the diagnosis of myocardial infarction. We will give an update of clinical studies addressing the role of circulating miRNA expression after myocardial infarction and explore the diagnostic value of this potential biomarker.

Keywords

ACS Circulating microRNAs Myocardial infarction Biomarkers