Journal of Cardiovascular Translational Research

, Volume 6, Issue 1, pp 22–30

A Review of Human Pluripotent Stem Cell-Derived Cardiomyocytes for High-Throughput Drug Discovery, Cardiotoxicity Screening, and Publication Standards

Authors

  • Nicholas M. Mordwinkin
    • Department of Medicine (Division of Cardiology)Stanford University
    • Institute for Stem Cell Biology and Regenerative MedicineStanford University
    • Stanford Cardiovascular InstituteStanford University
  • Paul W. Burridge
    • Department of Medicine (Division of Cardiology)Stanford University
    • Institute for Stem Cell Biology and Regenerative MedicineStanford University
    • Stanford Cardiovascular InstituteStanford University
    • Department of Medicine (Division of Cardiology)Stanford University
    • Institute for Stem Cell Biology and Regenerative MedicineStanford University
    • Stanford Cardiovascular InstituteStanford University
Article

DOI: 10.1007/s12265-012-9423-2

Cite this article as:
Mordwinkin, N.M., Burridge, P.W. & Wu, J.C. J. of Cardiovasc. Trans. Res. (2013) 6: 22. doi:10.1007/s12265-012-9423-2

Abstract

Drug attrition rates have increased in past years, resulting in growing costs for the pharmaceutical industry and consumers. The reasons for this include the lack of in vitro models that correlate with clinical results and poor preclinical toxicity screening assays. The in vitro production of human cardiac progenitor cells and cardiomyocytes from human pluripotent stem cells provides an amenable source of cells for applications in drug discovery, disease modeling, regenerative medicine, and cardiotoxicity screening. In addition, the ability to derive human-induced pluripotent stem cells from somatic tissues, combined with current high-throughput screening and pharmacogenomics, may help realize the use of these cells to fulfill the potential of personalized medicine. In this review, we discuss the use of pluripotent stem cell-derived cardiomyocytes for drug discovery and cardiotoxicity screening, as well as current hurdles that must be overcome for wider clinical applications of this promising approach.

Keywords

Pluripotent stem cellsCardiovascular diseaseToxicity screeningDrug discovery

Copyright information

© Springer Science+Business Media New York 2012