Article

Journal of Cardiovascular Translational Research

, Volume 5, Issue 4, pp 509-518

Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies

  • Mona SedeekAffiliated withOttawa Hospital Research Institute
  • , Augusto C. MontezanoAffiliated withOttawa Hospital Research Institute
  • , Richard L. HebertAffiliated withOttawa Hospital Research Institute
  • , Stephen P. GrayAffiliated withBaker IDI Heart & Diabetes Research Institute
  • , Elyse Di MarcoAffiliated withBaker IDI Heart & Diabetes Research InstituteDepartment of Medicine, Monash University
  • , Jay C. JhaAffiliated withBaker IDI Heart & Diabetes Research Institute
  • , Mark E. CooperAffiliated withBaker IDI Heart & Diabetes Research InstituteDepartment of Medicine, Monash UniversityDepartment of Immunology, Monash University
  • , Karin Jandeleit-DahmAffiliated withBaker IDI Heart & Diabetes Research InstituteDepartment of Medicine, Monash University
  • , Ernesto L. SchiffrinAffiliated withLady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University
    • , Jennifer L. Wilkinson-BerkaAffiliated withDepartment of Immunology, Monash University
    • , Rhian M. TouyzAffiliated withOttawa Hospital Research InstituteInstitute for Cardiovascular and Medical sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow Email author 

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Abstract

Most diabetes-related complications and causes of death arise from cardiovascular disease and end-stage renal disease. Amongst the major complications of diabetes mellitus are retinopathy, neuropathy, nephropathy and accelerated atherosclerosis. Increased bioavailability of reactive oxygen species (ROS) (termed oxidative stress), derived in large part from the NADPH oxidase (Nox) family of free radical producing enzymes, has been demonstrated in experimental and clinical diabetes and has been implicated in the cardiovascular and renal complications of diabetes. The present review focuses on the role of Noxs and oxidative stress in some major complications of diabetes, including nephropathy, retinopathy and atherosclerosis. We also discuss Nox isoforms as potential targets for therapy.

Keywords

Diabetic nephropathy Cardiovascular disease NADPH oxidase Diabetes mellitus Nox isoforms