Journal of Cardiovascular Translational Research

, Volume 5, Issue 4, pp 509–518

Oxidative Stress, Nox Isoforms and Complications of Diabetes—Potential Targets for Novel Therapies

Authors

  • Mona Sedeek
    • Ottawa Hospital Research Institute
  • Augusto C. Montezano
    • Ottawa Hospital Research Institute
  • Richard L. Hebert
    • Ottawa Hospital Research Institute
  • Stephen P. Gray
    • Baker IDI Heart & Diabetes Research Institute
  • Elyse Di Marco
    • Baker IDI Heart & Diabetes Research Institute
    • Department of MedicineMonash University
  • Jay C. Jha
    • Baker IDI Heart & Diabetes Research Institute
  • Mark E. Cooper
    • Baker IDI Heart & Diabetes Research Institute
    • Department of MedicineMonash University
    • Department of ImmunologyMonash University
  • Karin Jandeleit-Dahm
    • Baker IDI Heart & Diabetes Research Institute
    • Department of MedicineMonash University
  • Ernesto L. Schiffrin
    • Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General HospitalMcGill University
  • Jennifer L. Wilkinson-Berka
    • Department of ImmunologyMonash University
    • Ottawa Hospital Research Institute
    • Institute for Cardiovascular and Medical sciences, BHF Glasgow Cardiovascular Research CentreUniversity of Glasgow
Article

DOI: 10.1007/s12265-012-9387-2

Cite this article as:
Sedeek, M., Montezano, A.C., Hebert, R.L. et al. J. of Cardiovasc. Trans. Res. (2012) 5: 509. doi:10.1007/s12265-012-9387-2

Abstract

Most diabetes-related complications and causes of death arise from cardiovascular disease and end-stage renal disease. Amongst the major complications of diabetes mellitus are retinopathy, neuropathy, nephropathy and accelerated atherosclerosis. Increased bioavailability of reactive oxygen species (ROS) (termed oxidative stress), derived in large part from the NADPH oxidase (Nox) family of free radical producing enzymes, has been demonstrated in experimental and clinical diabetes and has been implicated in the cardiovascular and renal complications of diabetes. The present review focuses on the role of Noxs and oxidative stress in some major complications of diabetes, including nephropathy, retinopathy and atherosclerosis. We also discuss Nox isoforms as potential targets for therapy.

Keywords

Diabetic nephropathy Cardiovascular disease NADPH oxidase Diabetes mellitus Nox isoforms

Copyright information

© Springer Science+Business Media, LLC 2012