Journal of Cardiovascular Translational Research

, Volume 5, Issue 3, pp 256–263

Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet

Authors

  • Marie Billaud
    • Robert M. Berne Cardiovascular Research CenterUniversity of Virginia School of Medicine
  • Scott R. Johnstone
    • Robert M. Berne Cardiovascular Research CenterUniversity of Virginia School of Medicine
    • Robert M. Berne Cardiovascular Research CenterUniversity of Virginia School of Medicine
    • Department of Molecular Physiology and Biological PhysicsUniversity of Virginia School of Medicine
Article

DOI: 10.1007/s12265-012-9354-y

Cite this article as:
Billaud, M., Johnstone, S.R. & Isakson, B.E. J. of Cardiovasc. Trans. Res. (2012) 5: 256. doi:10.1007/s12265-012-9354-y

Abstract

Arterial stiffness is a key marker in metabolic diseases and can be evaluated by arterial compliance. Most compliance measurements are performed in large conduit arteries in advanced stage of metabolic diseases, which may not provide information on mechanisms associated with the initiation of the pathology. For this reason, we compared arterial compliance of two different size arteries: carotid and a smaller artery (thoracodorsal artery, TDA). The arterial compliance was compared between control and high fat-fed mice for 6 weeks. We show that the compliance of the TDAs was dramatically reduced in high fat-fed mice whereas the compliance of the carotids remained unchanged. An abundance of collagen deposition in the media/adventitia of the carotids and TDAs was observed in high fat-fed mice. These results demonstrate that the structural and mechanical properties of small arteries are rapidly altered even after only 6 weeks of high fat feeding.

Keywords

CompliancePressure–diameter responseObesityMetabolic diseases

Copyright information

© Springer Science+Business Media, LLC 2012