Biomaterials to Prevascularize Engineered Tissues


DOI: 10.1007/s12265-011-9301-3

Cite this article as:
Tian, L. & George, S.C. J. of Cardiovasc. Trans. Res. (2011) 4: 685. doi:10.1007/s12265-011-9301-3


Tissue engineering promises to restore tissue and organ function following injury or failure by creating functional and transplantable artificial tissues. The development of artificial tissues with dimensions that exceed the diffusion limit (1–2 mm) will require nutrients and oxygen to be delivered via perfusion (or convection) rather than diffusion alone. One strategy of perfusion is to prevascularize tissues; that is, a network of blood vessels is created within the tissue construct prior to implantation, which has the potential to significantly shorten the time of functional vascular perfusion from the host. The prevascularized network of vessels requires an extracellular matrix or scaffold for 3D support, which can be either natural or synthetic. This review surveys the commonly used biomaterials for prevascularizing 3D tissue engineering constructs.


Prevascularization Tissue engineering Natural Synthetic Scaffold 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.The Edwards Lifesciences Center for Advanced Cardiovascular TechnologyUniversity of CaliforniaIrvineUSA
  2. 2.Department of Biomedical EngineeringUniversity of CaliforniaIrvineUSA
  3. 3.Department of Chemical Engineering and Material ScienceUniversity of CaliforniaIrvineUSA

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